Devices and methods for non-invasive optical physiological measurements

• US 8,761,853 B2
• Filed: 01/20/2011
• Issued: 06/24/2014
• Est. Priority Date: 01/20/2011
• Status: Active Grant

• Current Assignee: Nitto Denko Corporation
• Original Assignee: Nitto Denko Corporation
• Inventors: Thaveeprungsriporn, Visit, Naing, Nyan Myo, Samsudin, Mohamad Sulhede Bin, Kassim, Md Irwan Bin Md
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US13/010,705
• Publication Number:
  US 20120190944A1
• Time in Patent Office: 1,251 Days
• Field of Search: 600/310, 600/322, 600/323, 600/324, 600/335, 600/344
• US Class Current: 600/323
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 2562/227 Sensors with electrical connectors
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/6843 Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61B 5/6898 Portable consumer electronic devices, e.g. music players, telephones, tablet computers
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7435 Displaying user selection data, e.g. icons in a graphical user interface
• CPC Class Codes: F04C 2270/041 Controlled or regulated
• CPC Class Codes: G01N 2021/3144 for oxymetry
• CPC Class Codes: G01N 21/3151 using two sources of radiation of different wavelengths G01N21/33 - G01N21/39 take precedence

Abstract

An optical measurement device and method of use provides non-invasive physiological measurements from a predetermined location on a body part of a user. The optical measurement device provides an illumination and detection assembly configured to generate and detect light of a predetermined wavelength range in the form of a photoplethysmography (PPG) signal, as well as a pressure detection assembly configured to detect an amount of pressure applied to the measurement device by the user being measured. A feedback unit, such as a portable display device, provides the user real-time feedback of the detected PPG signal and level of applied pressure so that the user may adjust the amount of applied pressure to improve the quality of the detected PPG signal.

Claims

1. An optical measurement device comprising:

an illumination and detection assembly configured to output light to a portion of living tissue of a user and detect transmitted or reflected light as a signal; and

a pressure assembly configured to detect an amount of pressure applied to the illumination and detection assembly by the portion of living tissue of the user,

wherein the illumination and detection assembly and the pressure assembly are capable of communicating with a feedback unit configured to correlate a quality of the detected signal with the amount of applied pressure

by;

computing an area under waveforms of detected signals corresponding to a variety of applied pressure amounts, and

determining an optimum pressure to correspond a largest computed area, from the variety of applied pressure amounts,

wherein the feedback unit is further configured to provide a feedback related to the optimum pressure to the user.

2. The optical measurement device of claim 1, wherein the feedback is an indication of whether the user should adjust the amount of pressure being applied to the illumination and detection assembly.

3. The optical measurement device of claim 2, wherein the feedback is displayed as a range of optimal applied pressures along with the actual applied pressure being applied by the user.

4. The optical measurement device of claim 3, wherein the range of optimal applied pressures corresponds to a state of zero transmural pressure.

5. The optical measurement device of claim 2, wherein the feedback is a request to the user to increase, decrease or maintain the applied pressure.

6. The optical measurement device of claim 1, wherein the feedback is a real-time visual output of the detected signal and detected applied pressure.

7. The optical measurement device of claim 1, wherein the feedback unit is a portable computer including a processor, memory and a display.

8. The optical measurement device of claim 7, wherein the illumination and detection assembly, pressure assembly and feedback unit are integrated into a portable device.

9. The optical measurement device of claim 8, wherein the portable device is configured with a plurality of illumination and detection assemblies and a plurality of pressure assemblies.

10. The optical measurement device as claimed in claim 7, wherein the portable computer comprises one of a mobile phone, a smartphone, a personal digital assistant (PDA), a tablet, a netbook and a laptop.

11. The optical measurement device of claim 1, wherein the illumination and detection assembly and the pressure assembly are capable of communicating with the feedback unit over a wireless network.

12. The optical measurement device of claim 1, wherein the detected signal is a photoplethysmography (PPG) signal.

13. The optical measurement device of claim 1, wherein the illumination and detection assembly and pressure assembly are integrated into a single portable device.

14. The optical measurement device of claim 13, wherein the feedback unit is provided separately and is configured to be connectable to the optical measurement device.

15. The optical measurement device of claim 1, wherein the pressure assembly comprises a thin film flexible printed circuit.

16. The optical measurement device of claim 1, wherein the illumination and detection assembly comprises a red light emitting diode (LED), an infra-red LED or both.

17. The optical measurement device of claim 16, wherein saturation of peripheral oxygen (SPO₂) information of the user is derivable from the detected light information from both the red LED and the infra-red LED.

18. A method for detecting a physiological signal using an optical measurement device, the method comprising:

illuminating a portion of living tissue of a user and detecting transmitted or reflected light as a signal using an illumination and detection assembly;

detecting an amount of pressure applied by the portion of living tissue of the user to the illumination and detection assembly using a pressure detection assembly; and

correlating a quality of the detected signal with the amount of applied pressure;

computing an area under waveforms of detected signals corresponding to a variety of applied pressure amounts, and

determining an optimum pressure to correspond a largest computed area, from the variety of applied pressure amounts.

19. The method of claim 18, further comprising providing feedback related to the optimum pressure to the user using a feedback unit.

20. The method of claim 19, wherein the step of providing feedback comprises providing an indication to the user of whether the amount of pressure being applied to the illumination and detection assembly should be adjusted.

21. The method of claim 20, wherein the step of providing feedback further comprises displaying a range of optimal applied pressures along with the actual applied pressure being applied by the user.

22. The method of claim 21, wherein the step of providing feedback further comprises displaying a range of optimal applied pressures which corresponds to a state of zero transmural pressure.

23. The method of claim 20, wherein the step of providing feedback further comprises requesting the user to increase, decrease or maintain the applied pressure.

24. The method of claim 19, wherein the step of providing feedback further comprises displaying a real-time visual output of the detected signal and the detected applied pressure.

25. The method of claim 19, wherein the feedback unit is a portable computer including a processor, memory and a display.

26. The method of claim 25, wherein the illumination and detection assembly, pressure assembly and feedback unit are integrated into a portable device.

27. The method of claim 26, wherein the portable device is configured with a plurality of illumination and detection assemblies and a plurality of pressure assemblies.

28. The method of claim 25, wherein the portable computer is one selected from the group consisting of a mobile phone, a smartphone, a personal digital assistant (PDA), a tablet, a netbook and a laptop.

29. The method of claim 19, wherein the step of providing feedback comprises wirelessly communicating between the feedback unit and the illumination and detection assembly and pressure assembly.

30. The method of claim 18, wherein the detected signal is a photoplethysmography (PPG) signal.

31. The method of claim 19, wherein the illumination and detection assembly and pressure assembly are integrated into a single portable device.

32. The method of claim 31, wherein the feedback unit is provided separately and is configured to be connectable to the optical measurement device.

33. The method of claim 18, wherein the pressure assembly comprises a thin film flexible printed circuit.

34. The method of claim 18, wherein the illumination and detection assembly comprises a red light emitting diode (LED), an infra-red LED or both.

35. The method of claim 34, further comprising deriving saturation of peripheral oxygen (SPO₂) information of the user from the detected output light information from both the red LED and the infra-red LED.

36. A computer program product for detecting a physiological signal using an optical measurement device, the computer program product embodied on a computer readable medium and when executed by a computer with a processor and a memory, performs the method comprising:

illuminating a portion of living tissue of a user and detecting transmitted or reflected light as a signal using an illumination and detection assembly;

detecting an amount of pressure applied by the portion of living tissue of the user to the illumination and detection assembly; and

correlating a quality of the detected signal with the amount of applied pressure;

computing an area under waveforms of detected signals corresponding to a variety of applied pressure amounts, and

determining an optimum pressure to correspond a largest computed area, from the variety of applied pressure amounts.

37. The computer program product of claim 36, wherein the method further comprises providing feedback related to the optimum pressure to the user.

38. An optical measurement system comprising:

an optical measurement device comprising;

an illumination and detection assembly configured to output light to a portion of living tissue of a user and detect transmitted or reflected light as a signal; and

a pressure assembly configured to detect an amount of pressure applied to the illumination and detection assembly by the portion of living tissue of the user; and

a feedback unit connected to the optical measurement device, and configured to correlate a quality of the detected signal with the amount of applied pressure

by;

computing an area under waveforms of detected signals corresponding to a variety of applied pressure amounts, and

determining an optimum pressure to correspond a largest computed area, from the variety of applied pressure amounts,

wherein the feedback unit is further configured to provide a feedback related to the optimum pressure to the user.