Electrical stimulation programming

• US 8,761,890 B2
• Filed: 01/24/2013
• Issued: 06/24/2014
• Est. Priority Date: 04/10/2012
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Gupta, Rahul, Goetz, Steven M., Lazarewicz, Maciej T., Molnar, Gabriela C., Nelson, Dwight E., Wu, Jianping
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US13/748,633
• Publication Number:
  US 20130268019A1
• Time in Patent Office: 516 Days
• Field of Search: 607/45
• US Class Current: 607/45
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36164 Sub-threshold or non-excitatory signals non-excitatory signals to the heart A61N1/3628
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

In one example, the disclosure relates to a method comprising receiving at least one electrical stimulation parameter value defining electrical stimulation for delivery via one or more electrodes to a tissue site, and determining, via one or more processors, a volume of sub-activation threshold impact for tissue from the delivery of the electrical stimulation to the tissue site.

Claims

1. A method comprising:

receiving at least one electrical stimulation parameter value defining electrical stimulation for delivery via one or more electrodes to a tissue site; and

determining, via one or more processors, a volume of sub-activation threshold impact from the delivery of the electrical stimulation to the tissue site, wherein the volume of sub-activation threshold impact is defined by a volume of tissue electrically influenced by the electrical stimulation but in which neurons are not directly activated by the electrical stimulation.

2. The method of claim 1, further comprising displaying a representation of the determined volume of sub-activation threshold impact via a user interface.

3. The method of claim 2, further comprising displaying an image of an anatomical region relative to the representation of the determined volume of sub-activation threshold impact via the user interface.

4. The method of claim 2, further comprising displaying a representation of the one or more electrodes relative to the representation of the determined volume of sub-activation threshold impact via the user interface.

5. The method of claim 2, further comprising displaying an image of an anatomical region and the one or more electrodes relative to the representation of the determined volume of sub-activation threshold impact via the user interface.

6. The method of claim 5, further comprising:

receiving user input modifying a position of one or more of the electrodes relative to the image of the anatomical region; and

repositioning the representation of the determined volume of sub-activation threshold impact relative the anatomical image based on the modified position of the one or more electrodes.

7. The method of claim 2, further comprising:

determining, via the one or more processors, a volume of tissue activation from the delivery of the electrical stimulation to the tissue site; and

displaying a representation of the determined volume of tissue activation in combination with the representation of the determined volume of tissue sub-activation threshold impact via the user interface.

8. The method of claim 1, wherein the volume of sub-activation threshold impact comprises a first volume of sub-activation threshold impact, the method further comprising:

receiving a modification to one or more of the at least one electrical stimulation parameter value defining the electrical stimulation or the one or more electrodes; and

determining, via one or more processors, a second volume of sub-activation threshold impact for tissue from the delivery of the modified electrical stimulation to the tissue site.

9. The method of claim 8, further comprising displaying, via a user interface, a representation of the first volume of sub-activation threshold impact and the modified volume of sub-activation threshold impact.

10. The method of claim 1, wherein determining, via one or more processors, the volume of sub-activation threshold impact for tissue from the delivery of the electrical stimulation to the tissue site comprises:

delivering the electrical stimulation to the tissue site;

sensing electrical signals via one or more electrodes in conjunction with the delivery of electrical stimulation to the tissue site at one or more locations; and

determining the volume of sub-activation threshold impact for tissue from the delivery of the electrical stimulation to the tissue site based on the sensed electrical signals.

11. The method of claim 1, further comprising:

receiving an indication of a target volume of sub-activation threshold impact for tissue; and

determining one or more electrical stimulation parameter values for electrical stimulation for delivery via the one or more electrodes to result in the target volume of volume of sub-activation threshold impact.

12. A system comprising one or more processors configured to receive at least one electrical stimulation parameter value defining electrical stimulation for delivery via one or more electrodes to a tissue site, and determine a volume of sub-activation threshold impact from the delivery of the electrical stimulation to the tissue site, wherein the volume of sub-activation threshold impact is defined by a volume of tissue electrically influenced by the electrical stimulation but in which neurons are not directly activated by the electrical stimulation.

13. The system of claim 12, further comprising a user interface configured to display a representation of the determined volume of sub-activation threshold impact.

14. The system of claim 13, wherein the user interface is configured to display an image of an anatomical region relative to the representation of the determined volume of sub-activation threshold impact.

15. The system of claim 13, wherein the user interface is configured to display a representation of the one or more electrodes relative the representation of the determined volume of sub-activation threshold impact.

16. The system of claim 13, wherein the user interface is configured to display an image of an anatomical region and an image of the one or more electrodes relative the representation of the determined volume of sub-activation threshold impact.

17. The system of claim 16, wherein the one or more processors are configured to receive user input modifying a position of an image of one or more of the electrodes relative to the image of the anatomical region displayed by the user interface, and based on the user input, to reposition the representation of the determined volume of sub-activation threshold impact relative to the anatomical image displayed by the user interface.

18. The system of claim 13, wherein the one or more processors are configured to determine a volume of tissue activation from the delivery of the electrical stimulation to the tissue site, and wherein the user interface is configured to display a representation of the determined volume of tissue activation in combination with the representation of the determined volume of tissue sub-activation threshold impact via the user interface.

19. The system of claim 12, wherein the volume of sub-activation threshold impact comprises a first volume of sub-activation threshold impact, wherein the one or more processors are configured to receive a modification to one or more of the at least one electrical stimulation parameter value defining electrical stimulation or the one or more electrodes, and determine a second volume of sub-activation threshold impact for tissue from the delivery of the modified electrical stimulation to the tissue site.

20. The system of claim 19, further comprising a user interface configured to display a representation of the first volume of sub-activation threshold impact and the modified volume of sub-activation threshold impact.

21. The system of claim 12, wherein the one or more processors are configured to control the delivery of the electrical stimulation to the tissue site, sense electrical signals via one or more electrodes in conjunction with the delivery of electrical stimulation to the tissue site at one or more locations, and determine the volume of sub-activation threshold impact for tissue from the delivery of the electrical stimulation to the tissue site based on the sensed electrical signals.

22. The system of claim 12, wherein the one or more processors are configured to receive an indication of a target volume of sub-activation threshold impact for tissue, and determine one or more electrical stimulation parameter value for electrical stimulation for delivery via the one or more electrodes to result in the target volume of sub-activation threshold impact.

23. A system comprising:

means for receiving at least one electrical stimulation parameter value defining electrical stimulation for delivery via one or more electrodes to a tissue site; and

means for determining a volume of sub-activation threshold impact from the delivery of the electrical stimulation to the tissue site, wherein the volume of sub-activation threshold impact is defined by a volume of tissue electrically influenced by the electrical stimulation but in which neurons are not directly activated by the electrical stimulation.

24. A non-transitory computer-readable storage medium including instructions to cause one or more processors to:

receive at least one electrical stimulation parameter value defining electrical stimulation for delivery via one or more electrodes to a tissue site; and

determine a volume of sub-activation threshold impact from the delivery of the electrical stimulation to the tissue site, wherein the volume of sub-activation threshold impact is defined by a volume of tissue electrically influenced by the electrical stimulation but in which neurons are not directly activated by the electrical stimulation.

25. A system comprising one or more processors configured to receive an indication of a target volume of sub-activation threshold impact for tissue, and determine one or more electrical stimulation parameter values for electrical stimulation for delivery via the one or more electrodes to result in the target volume of sub-activation threshold impact, wherein the volume of sub-activation threshold impact is defined by a volume of tissue electrically influenced by the electrical stimulation but in which neurons are not directly activated by the electrical stimulation.