Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
First Claim
Patent Images
1. A computer-implemented method, comprising:
- administering with a predetermined velocity a plurality of frozen particle compositions, including at least two subsets including different therapeutic or reinforcement agents and at least one tracer agent, to at least one surface of at least one biological tissue of a subject in a manner sufficient to abrade the at least one surface of the at least one biological tissue;
comparing, using one or more microprocessors, information regarding at least one aspect of cellular or tissue abrasion or ablation of the at least one biological tissue of at least one subject, and information regarding at least one clinical outcome following receipt by the at least one subject of the plurality of frozen particle compositions;
measuring a signal from the at least one tracer agent;
communicating real-time feedback control of the amount of a frozen particle composition delivered to the at least one subject based on the measurement of the signal from the at least one tracer agent; and
providing output information, including at least one of a response signal, a comparison code, a comparison plot, a diagnostic code, a treatment code, a test code, a code indicative of at least one treatment received, a code indicative of at least one prescribed treatment step, a code indicative of at least one vaccination delivered;
a code indicative of at least one therapeutic agent delivered;
a code indicative of at least one diagnostic agent delivered;
a code indicative of at least one interaction of a delivered agent and at least one biological or chemical agent in the subject;
a code indicative of at least one dispersion or location of at least one delivered agent;
a code indicative of at least one detection material delivered;
a code indicative of the depth of penetration of a delivered agent;
or a code indicative of the condition of at least one location of an administered frozen particle composition.
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Abstract
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
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Citations
48 Claims
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1. A computer-implemented method, comprising:
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administering with a predetermined velocity a plurality of frozen particle compositions, including at least two subsets including different therapeutic or reinforcement agents and at least one tracer agent, to at least one surface of at least one biological tissue of a subject in a manner sufficient to abrade the at least one surface of the at least one biological tissue; comparing, using one or more microprocessors, information regarding at least one aspect of cellular or tissue abrasion or ablation of the at least one biological tissue of at least one subject, and information regarding at least one clinical outcome following receipt by the at least one subject of the plurality of frozen particle compositions; measuring a signal from the at least one tracer agent; communicating real-time feedback control of the amount of a frozen particle composition delivered to the at least one subject based on the measurement of the signal from the at least one tracer agent; and providing output information, including at least one of a response signal, a comparison code, a comparison plot, a diagnostic code, a treatment code, a test code, a code indicative of at least one treatment received, a code indicative of at least one prescribed treatment step, a code indicative of at least one vaccination delivered;
a code indicative of at least one therapeutic agent delivered;
a code indicative of at least one diagnostic agent delivered;
a code indicative of at least one interaction of a delivered agent and at least one biological or chemical agent in the subject;
a code indicative of at least one dispersion or location of at least one delivered agent;
a code indicative of at least one detection material delivered;
a code indicative of the depth of penetration of a delivered agent;
or a code indicative of the condition of at least one location of an administered frozen particle composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A computer-implemented method of predicting a clinical outcome of at least one frozen particle composition treatment for at least one first subject, comprising:
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administering with a predetermined velocity a plurality of frozen particle compositions including at least two subsets including different therapeutic or reinforcement agents and at least one tracer agent;
to at least one surface of at least one biological tissue of a subject in a manner sufficient to abrade the at least one surface of the at least one biological tissue;determining, using one or more microprocessors, a similarity or a dissimilarity in information regarding at least one aspect of cellular or tissue abrasion or ablation of at least one biological tissue of at least one first subject to information regarding at least one aspect of cellular or tissue abrasion or ablation of at least one biological tissue of at least one second subject, wherein the at least one second subject attained a clinical outcome following receipt of at least one frozen particle composition; measuring a signal from the at least one tracer agent; communicating in real-time feedback control of the amount of a frozen particle composition delivered to the at least one subject based on the measurement of the signal from the at least one tracer agent; and providing output information, including at least one of a response signal, a comparison code, a comparison plot, a diagnostic code, a treatment code, a test code, a code indicative of at least one treatment received, a code indicative of at least one prescribed treatment step, a code indicative of at least one vaccination delivered;
a code indicative of at least one therapeutic agent delivered;
a code indicative of at least one diagnostic agent delivered;
a code indicative of at least one interaction of a delivered agent and at least one biological or chemical agent in the subject;
a code indicative of at least one dispersion or location of at least one delivered agent;
a code indicative of at least one detection material delivered;
a code indicative of the depth of penetration of a delivered agent;
or a code indicative of the condition of at least one location of an administered frozen particle composition. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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48. A computer-implemented method, comprising:
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selecting, using one or more microprocessors, a combination of at least two parameters selected from quality or quantity related to one or more frozen particle compositions that include at least one tracer agent;
method of delivery of one or more frozen particle compositions;
delivery location of one or more frozen particle compositions;
content of one or more frozen particle compositions;
timing of delivery of one or more frozen particle compositions;
decrease in physical dimension of one or more frozen particle compositions;
or time interval between at least two subset deliveries with one or more pluralities of frozen particle compositions;administering with a predetermined velocity the selected plurality of frozen particle compositions to at least one surface of at least one biological tissue of a subject in a manner sufficient to abrade the at least one surface of the at least one biological tissue; comparing, using one or more microprocessors, information regarding at least one aspect of cellular or tissue abrasion or ablation of the at least one biological tissue of at least one subject, and information regarding at least one clinical outcome following receipt by the at least one subject of the at least one frozen particle composition; measuring a signal from the at least one tracer agent, communicating real-time feedback control of the amount of a frozen particle composition delivered to the at least one subject based on the measurement of the signal from the at least one tracer agent; and providing output information, including at least one of a response signal, a comparison code, a comparison plot, a diagnostic code, a treatment code, a test code, a code indicative of at least one treatment received, a code indicative of at least one prescribed treatment step, a code indicative of at least one vaccination delivered;
a code indicative of at least one therapeutic agent delivered;
a code indicative of at least one diagnostic agent delivered;
a code indicative of at least one interaction of a delivered agent and at least one biological or chemical agent in the subject;
a code indicative of at least one dispersion or location of at least one delivered agent;
a code indicative of at least one detection material delivered;
a code indicative of the depth of penetration of a delivered agent;
or a code indicative of the condition of at least one location of an administered frozen particle composition.
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Specification