Wireless monitoring of laboratory animals

• US 8,763,559 B2
• Filed: 02/26/2013
• Issued: 07/01/2014
• Est. Priority Date: 10/12/2009
• Status: Active Grant

• Current Assignee: Vertex Pharmaceuticals Incorporated
• Original Assignee: Vertex Pharmaceuticals Incorporated
• Inventors: Salzmann, Philip, Nguyen, Trang, Sinclair, James
• Primary Examiner(s): Hayes, Kristen C
• Application Number:
  US13/777,239
• Publication Number:
  US 20130176035A1
• Time in Patent Office: 490 Days
• Field of Search: 119/421
• US Class Current: 119/421
• CPC Class Codes: A01K 1/031 Cages for laboratory animals; Cages for measuring metabolism of animals
• CPC Class Codes: A01K 11/006 Automatic identification systems for animals, e.g. electronic devices, transponders for animals identification systems for access to feeding pens A01K1/0209; ear tags with electronic identification means A01K11/004
• CPC Class Codes: A01K 29/005 Monitoring or measuring activity, e.g. detecting heat or mating
• CPC Class Codes: G01N 27/028 Circuits therefor measuring impedance per se G01R27/02

Abstract

Systems and methods for monitoring laboratory animals includes a tag comprising an inductive element and a capacitive element attached to a portion of a laboratory animal. The position of the portion is detected by monitoring the effect of the tag on a time-varying magnetic field having different frequencies, one near tag resonance, and one away from tag resonance.

Claims

1. A cage for holding and monitoring a rodent comprising:

a bridge of four legs comprising;

a first coil positioned below a floor of the cage; and

a second coil positioned above the floor of the cage;

a resonant circuit attached to a portion of a laboratory animal, said resonant circuit defining a resonant frequency;

a signal generator electrically coupled to at least one coil configured to drive the at least one coil with at least a first drive signal comprising a first frequency and a second drive signal comprising a second frequency, wherein the second frequency is more distant from said resonant frequency than the first frequency; and

a detection circuit comprising a differential amplifier electrically coupled to at least one coil and configured to detect an impedance change in said at least one coil between application of said first frequency to said at least one coil and application of said second frequency to said at least one coil, and to generate an output signal representative of resonant circuit position with respect to said at least one coil based at least in part on said impedance change;

wherein the signal generator is coupled to a first and second node of said bridge, the first and second nodes being opposite nodes and wherein the detection circuit is coupled to a third and fourth node of said bridge, the third and fourth nodes being opposite nodes.

2. The cage of claim 1, wherein said first coil, said second coil, and said floor are substantially aligned along a common longitudinal axis.

3. The cage of claim 1, wherein said floor is positioned at approximately a midpoint between said first coil and said second coil.

4. The cage of claim 1, wherein the first coil and the second coil are disposed parallel to the floor.

5. The cage of claim 1, wherein the detection circuit comprises an envelope detector electrically coupled to said differential amplifier.

6. The system of claim 5, wherein the detection circuit comprises a sampling circuit coupled to the envelope detector.

7. The cage of claim 1, wherein said resonant circuit comprises an inductor and a capacitor electrically coupled in parallel.

8. The cage of claim 7, wherein the resonant circuit is mounted to a printed circuit board.

9. The cage of claim 1, wherein the output signal is representative of the vertical position of the resonant circuit above the floor.

10. The cage of claim 1, wherein the first and second coil are wired in series forming two legs of the four legs, and wherein the other two legs of the bridge comprise two resistors, one resistor in each leg.