Rotary cassette system for dry powder inhaler

• US 8,763,606 B2
• Filed: 05/21/2010
• Issued: 07/01/2014
• Est. Priority Date: 05/21/2009
• Status: Active Grant

• Current Assignee: MicroDose Therapeutx, Inc. (Teva Pharmaceutical Industries Limited)
• Original Assignee: MicroDose Therapeutx, Inc. (Teva Pharmaceutical Industries Limited)
• Inventors: Mosier, Kent D., Brandt-Madsen, Brian, Lassen, Steen G., Andersen, Morten E., Olesen, Jan
• Primary Examiner(s): Hand, Melanie
• Assistant Examiner(s): Heffner, Ned T
• Application Number:
  US12/785,082
• Publication Number:
  US 20100294278A1
• Time in Patent Office: 1,502 Days
• Field of Search: 128/203.12, 128/203.15, 128/203.19, 128/203.21, 128/200.16, 12820011-20023, 606/181, 600/583, 600/873, 600/181, 600/533, 600/535, 206/367, 206/535, 206/533
• US Class Current: 128/203.15
• CPC Class Codes: A61M 15/001 using ultrasonic means
• CPC Class Codes: A61M 15/0025 with caps
• CPC Class Codes: A61M 15/0035 Piercing means
• CPC Class Codes: A61M 15/0041 with movable piercing or cutting means
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/005 the dosages being arranged on a cylindrical surface
• CPC Class Codes: A61M 15/0063 Storages for pre-packed dosages
• CPC Class Codes: A61M 15/0075 on a disc
• CPC Class Codes: A61M 15/0083 Timers
• CPC Class Codes: A61M 2016/0024 with an on-off output signal, e.g. from a switch
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/0294 Piezoelectric materials
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/587 Lighting arrangements
• CPC Class Codes: A61M 2205/8206 battery-operated

Abstract

The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein a plurality of individual blister packs are arranged in a rotary cassette that fits within a housing, and wherein the individual blister packs are dragged up into a clamping position between the vibration element and a piercing element. The motion of the blister pack is controlled by a rotary disk within the housing which further coordinates the movement of the piercing and vibrating elements for the piercing and deaggregation, respectively, of the individual blister packs.

Claims

1. A medication inhaler, comprising a housing;

a mouthpiece affixed to the housing;

a vibrating element and a piercing element contained within the housing;

a plurality of individually addressable blister packs detachably carried on a cassette within the housing, wherein each of the plurality of individually addressable blister packs contains a specified amount of a medicament;

a blister-carrying mechanism disposed to move a selected blister pack between a stowed position and a detached dispensing position; and

a blister-clamping mechanism disposed to secure the selected blister pack in spring urged contact with the vibrating element.

2. The inhaler of claim 1 wherein the cassette is rotatably mounted within the housing.

3. The inhaler of claim 1, further comprising a rotatably mounted disk that coordinates movement of one of said plurality of individual blister packs into the dispensing position where an individual blister pack is clamped in between the vibrating element and the piercing element, in contact with the vibrating element.

4. The inhaler of claim 3, wherein the rotary disk further coordinates the movement of the piercing element, whereby the piercing element pierces the blister pack in the dispensing position.

5. The inhaler of claim 3, wherein the rotary disk further coordinates movement of the vibrating element whereupon the vibrating element comes into contact with the blister pack in the dispensing position.

6. The inhaler of claim 3, wherein the rotation of the disk is controlled by a user by using a lever arm that protrudes from the housing.

7. The inhaler of claim 3, further comprising a cover for covering the mouthpiece pivotally connected to the housing.

8. The inhaler of claim 7, further comprising a linkage connecting the cover with the rotary disk, wherein the pivotal movement of the disk turns the rotatably mounted disk cover.

9. The inhaler of claim 1, wherein the vibrating element is a piezoelectric transducer.

10. The inhaler of claim 1, further comprising a battery and a printed circuit board.

11. The inhaler of claim 1, wherein the plurality of individual blister packs are arranged in a circular plan, and wherein a plane of the blister pack is substantially perpendicular to a plane of the cassette.

12. The inhaler of claim 3, wherein the disk further coordinates the movement of the rotatably mounted cassette.

13. The inhaler of claim 1, wherein the medication comprises a dry powder.

14. The inhaler of claim 1, wherein the medication comprises a liquid.

15. A dry powder inhaler, comprising

a vibrating element;

a piercing element;

a cartridge carrying a plurality of individually addressable blister packs, wherein each of the plurality of individually addressable blister packs is detachable from the cartridge and contains a specified amount of powdered medicament, the blister packs being arranged in a circular formation on the cartridge; and

a lever arm, the movement of which causes a blister-carrying mechanism to move a selected blister pack from the cartridge to the piercing element and a blister-clamping mechanism to secure the selected blister pack in spring urged contact with the vibrating element, to be opened, deaggregated and the powder inhaled by a user.

16. The dry powder inhaler of claim 15, further comprising a disk that coordinates movement of the lever arm with the movement of one of said plurality of individual blister packs into an operative position.

17. The dry powder inhaler of claim 15, further comprising a flow channel connected at one end to a mouthpiece, the flow channel having an opening through which the top of a selected blister pack fits, the blister pack being held in place against the flow channel by the vibrating element, wherein the piercing element is located on the opposite side of the flow channel.

18. The dry powder inhaler of claim 17, further comprising a spring that urges the vibrating element against the selected blister pack.

19. The dry powder inhaler of claim 15, wherein the selected blister pack is dragged by a blister carrier which moves the selected blister pack in a radial direction.

20. The dry powder inhaler of claim 15, further comprising a flow sensor that senses the breath of the user.

21. The dry powder inhaler of claim 20, further comprising a battery and a microprocessor, wherein the microprocessor receives a signal from the flow sensor and controls the activation of the vibrating element.