Signal processing in physiological noise
First Claim
1. A method for estimating a response of at least a part of a physiological system to a first deterministic stimulus signal, the method comprising:
- receiving, at a computing device, a first signal measured from the physiological system in response to the first stimulus signal;
separating, using a processor, the measured first signal into a plurality of segments, each segment representing a response of the physiological system to a corresponding portion of the first stimulus signal;
generating, using a processor, a template signal representing the plurality of segments;
calculating, using a processor, a measure of similarity of each segment in the plurality of segments to the template signal to provide a set of scalar quantities, wherein calculating the measure of similarity comprises calculating a correlation between the segment and the template signal; and
determining, using a processor, a metric representing a characteristic of the response of at least a part of the physiological system to the first stimulus signal, wherein the metric is a ratio of a measure of central tendency to a measure of dispersion, wherein the measure of central tendency and the measure of dispersion are computed from the set of scalar quantities.
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Accused Products
Abstract
The invention relates to systems and methods for estimating a response of at least a part of a physiological system to a first deterministic stimulus signal. The methods include separating a measured first signal into a plurality of segments, each segment representing a response of the physiological system to a corresponding portion of the first stimulus signal and generating a template signal representing the plurality of segments. The methods further include calculating a measure of similarity of each segment in the plurality of segments to the template signal to provide a set of scalar quantities, and determining a metric representing a characteristic of the response of at least a part of the physiological system to the first stimulus signal.
20 Citations
43 Claims
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1. A method for estimating a response of at least a part of a physiological system to a first deterministic stimulus signal, the method comprising:
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receiving, at a computing device, a first signal measured from the physiological system in response to the first stimulus signal; separating, using a processor, the measured first signal into a plurality of segments, each segment representing a response of the physiological system to a corresponding portion of the first stimulus signal; generating, using a processor, a template signal representing the plurality of segments; calculating, using a processor, a measure of similarity of each segment in the plurality of segments to the template signal to provide a set of scalar quantities, wherein calculating the measure of similarity comprises calculating a correlation between the segment and the template signal; and determining, using a processor, a metric representing a characteristic of the response of at least a part of the physiological system to the first stimulus signal, wherein the metric is a ratio of a measure of central tendency to a measure of dispersion, wherein the measure of central tendency and the measure of dispersion are computed from the set of scalar quantities. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A system for estimating a response of at least a part of a physiological system to a first stimulus signal, the system comprising:
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a processor for; separating a first signal into a plurality of segments, each segment representing a response of the physiological system to a corresponding portion of the first stimulus signal, wherein the first signal is measured from the physiological system in response to the first stimulus signal, generating a template signal representing the plurality of segments, calculating a measure of similarity of each segment in the plurality of segments to the template signal to provide a set of scalar quantities, wherein calculating the measure of similarity comprises calculating a correlation between the segment and the template signal, and determining a metric representing a characteristic of the response of at least a part of the physiological system to the first stimulus signal, wherein the metric is a ratio of a measure of central tendency to a measure of dispersion, wherein the measure of central tendency and the measure of dispersion are computed from the set of scalar quantities; and a device for measuring the first signal. - View Dependent Claims (22, 23, 24, 25)
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26. A computer-readable medium storing a computer program for estimating a response of at least a part of a physiological system to a first deterministic stimulus signal, the computer program comprising instructions for causing a computer system to:
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receive a first signal measured from the physiological system in response to the first stimulus signal; separate the measured first signal into a plurality of segments, each segment representing a response of the physiological system to a corresponding portion of the first stimulus signal; generate a template signal representing the plurality of segments; calculate a measure of similarity of each segment in the plurality of segments to the template signal to provide a set of scalar quantities, wherein calculating the measure of similarity comprises calculating a correlation between the segment and the template signal; and determine a metric representing a characteristic of the response of at least a part of the physiological system to the first stimulus signal, wherein the metric is a ratio of a measure of central tendency to a measure of dispersion, wherein the measure of central tendency and the measure of dispersion are computed from the set of scalar quantities.
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27. A method for estimating a response of at least a part of a physiological system to a first deterministic stimulus signal, the method comprising:
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receiving, at a computing device, a first signal measured from the physiological system in response to the first stimulus signal; separating, using a processor, the measured first signal into a plurality of segments, each segment representing a response of the physiological system to a corresponding portion of the first stimulus signal; generating, using a processor, a template signal representing the plurality of segments, wherein the template signal is generated based on one or more parameters of a theoretical model of the physiological system; calculating, using a processor, a measure of similarity of each segment in the plurality of segments to the template signal to provide a set of scalar quantities; and determining, using a processor, a metric representing a characteristic of the response of at least a part of the physiological system to the first stimulus signal, wherein the metric is a ratio of a measure of central tendency to a measure of dispersion, wherein the measure of central tendency and the measure of dispersion are computed from the set of scalar quantities. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A system for estimating a response of at least a part of a physiological system to a first stimulus signal, the system comprising:
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a processor for; separating a first signal into a plurality of segments, each segment representing a response of the physiological system to a corresponding portion of the first stimulus signal, wherein the first signal is measured from the physiological system in response to the first stimulus signal, generating a template signal representing the plurality of segments, wherein the template signal is generated based on one or more parameters of a theoretical model of the physiological system, calculating a measure of similarity of each segment in the plurality of segments to the template signal to provide a set of scalar quantities, and determining a metric representing a characteristic of the response of at least a part of the physiological system to the first stimulus signal, wherein the metric is a ratio of a measure of central tendency to a measure of dispersion, wherein the measure of central tendency and the measure of dispersion are computed from the set of scalar quantities; and a device for measuring the first signal. - View Dependent Claims (39, 40, 41, 42)
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43. A computer-readable medium storing a computer program for estimating a response of at least a part of a physiological system to a first deterministic stimulus signal, the computer program comprising instructions for causing a computer system to:
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receive a first signal measured from the physiological system in response to the first stimulus signal; separate the measured first signal into a plurality of segments, each segment representing a response of the physiological system to a corresponding portion of the first stimulus signal; generate a template signal representing the plurality of segments, wherein the template signal is generated based on one or more parameters of a theoretical model of the physiological system; calculate a measure of similarity of each segment in the plurality of segments to the template signal to provide a set of scalar quantities; and determine a metric representing a characteristic of the response of at least a part of the physiological system to the first stimulus signal, wherein the metric is a ratio of a measure of central tendency to a measure of dispersion, wherein the measure of central tendency and the measure of dispersion are computed from the set of scalar quantities.
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Specification