Dialysis treatment devices for removing urea

• US 8,764,981 B2
• Filed: 11/15/2011
• Issued: 07/01/2014
• Est. Priority Date: 06/11/2009
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Ding, Yuanpang Samuel, Lo, Ying-Cheng
• Primary Examiner(s): Menon, Krishnan S
• Application Number:
  US13/296,522
• Publication Number:
  US 20120055864A1
• Time in Patent Office: 959 Days
• Field of Search: None
• US Class Current: 210/321.71
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: B01D 61/30 Accessories; Auxiliary operation

Abstract

Dialysis treatment devices and methods for removing urea from dialysis waste streams are provided. In a general embodiment, the present disclosure provides a dialysis treatment device including: 1) a first filter having a filtration membrane, 2) a urea removal unit having urease and in fluid communication with the first filter, and 3) a second filter having an ion rejection membrane and in fluid communication with the first filter and the urea removal unit.

Claims

1. A dialysis treatment device comprising:

a filter comprising an adsorption layer, a filtration membrane and an ion exchange sorbent; and

a urea removal unit in fluid communication with a filtrate stream of the filter, the urea removal unit comprising a urease layer, an ammonia sorbent layer and an ion rejection membrane.

2. The dialysis treatment device of claim 1, wherein the dialysis treatment device is contained within a cartridge for a wearable kidney.

3. The dialysis treatment of claim 1, wherein the ion exchange sorbent is an anion exchange sorbent, and wherein the ion rejection membrane is a cation rejection membrane or a reverse osmosis membrane.

4. The dialysis treatment device of claim 1 further comprising a pump positioned between the filter and the urea removal unit.

5. The dialysis treatment device of claim 1 further comprising an activated carbon unit in fluid communication with the filter.

6. The dialysis treatment device of claim 3, wherein the reverse osmosis membrane includes an ion coating to trap ionic compounds.

7. The dialysis treatment device of claim 1 further comprising a zirconium phosphate layer in fluid communication with at least one of the filter and the urea removal unit.

8. A dialysis treatment device comprising:

a filter that produces a first treated dialysis fluid in a first flow path, the filter including an adsorption layer, a filtration membrane and an ion exchange sorbent; and

a urea removal unit that produces a second treated dialysis fluid, the urea removal unit in fluid communication with a filtrate stream of the filter via a second flow path, the urea removal unit including a urease layer, an ammonia sorbent layer and an ion rejection membrane, and

wherein the first and second flow paths combine in a third flow path to form a combined treated fluid for subsequent treatment and/or recirculation.

9. The dialysis treatment device of claim 8, which is contained within a cartridge for a wearable kidney.

10. The dialysis treatment of claim 8, wherein the ion exchange sorbent is an anion exchange sorbent, and wherein the ion rejection membrane is a cation rejection membrane or a reverse osmosis membrane.

11. The dialysis treatment device of claim 8, wherein the second flow path includes a pump.

12. The dialysis treatment device of claim 8, which further includes an activated carbon unit in fluid communication with the filter.

13. The dialysis treatment device of claim 10, wherein the reverse osmosis membrane includes an ion coating to trap ionic compounds.

14. The dialysis treatment device of claim 8, which further includes a zirconium phosphate layer in fluid communication with at least one of the filter and the urea removal unit.

15. The dialysis treatment device of claim 8, wherein the second flow path includes a supplementary ammonia sorbent unit between the urea removal unit and the third flow path.