N-maleimidyl polymer derivatives

• US 8,765,111 B2
• Filed: 05/09/2013
• Issued: 07/01/2014
• Est. Priority Date: 02/22/2000
• Status: Active Grant

• Current Assignee: Nektar Therapeutics Incorporated
• Original Assignee: Nektar Therapeutics Incorporated
• Inventors: Shen, Xiaoming
• Primary Examiner(s): Fubara, Blessing M
• Application Number:
  US13/890,799
• Publication Number:
  US 20130253207A1
• Time in Patent Office: 418 Days
• Field of Search: 548/400, 548/517, 548/518, 548/519, 548/520, 548/523, 548/548, 424/78.08, 424/78.33
• US Class Current: 424/78.08
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 47/58 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• CPC Class Codes: A61K 47/60 the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• CPC Class Codes: A61K 47/65 Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
• CPC Class Codes: C08G 65/00 Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
• CPC Class Codes: C08G 65/33337 cyclic
• CPC Class Codes: C08G 65/33396 having oxygen in addition to nitrogen
• CPC Class Codes: C08G 65/48 Polymers modified by chemical after-treatment

Abstract

The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.

Claims

1. A multi-functional N-maleimidyl polymer derivative having the formula: