Optically encoded particles
First Claim
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1. A freestanding optically encoded particle, comprising:
- a first porous layer having a predetermined first porosity and thickness; and
a plurality of n additional porous layers having predetermined thicknesses and porosities, at least one of which has a predetermined porosity differing from said first porosity;
whereinsaid predetermined porosities and thicknesses of said first porous layer and said n additional porous layers are configured to produce an interference pattern in the reflectivity spectrum having a distinct series of peaks such that the interference pattern forms an optical signature having a particular predetermined code determined by the porosities and thicknesses of said first porous layer and said n additional porous layers a receptor or targeting moiety for binding a predetermined analyte, wherein said receptor or targeting moiety is within one or more of said first porous layer and said n additional porous layers; and
whereinthe particle has a diameter of a few hundred microns or less and is freestanding separated from any substrate.
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Abstract
The invention concerns a particle having a code embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum.
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Citations
27 Claims
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1. A freestanding optically encoded particle, comprising:
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a first porous layer having a predetermined first porosity and thickness; and a plurality of n additional porous layers having predetermined thicknesses and porosities, at least one of which has a predetermined porosity differing from said first porosity;
whereinsaid predetermined porosities and thicknesses of said first porous layer and said n additional porous layers are configured to produce an interference pattern in the reflectivity spectrum having a distinct series of peaks such that the interference pattern forms an optical signature having a particular predetermined code determined by the porosities and thicknesses of said first porous layer and said n additional porous layers a receptor or targeting moiety for binding a predetermined analyte, wherein said receptor or targeting moiety is within one or more of said first porous layer and said n additional porous layers; and
whereinthe particle has a diameter of a few hundred microns or less and is freestanding separated from any substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 27)
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- 16. A freestanding encoded micron-sized porous particle having a particular predetermined code embedded in its physical porous structure by refractive index changes between different porous regions of the particle and a receptor or targeting moiety within said porous structure, wherein the physical porous structure has a plurality of layers some of which have separate predetermined mismatched optical thicknesses and the particle has a diameter of a few hundred microns or less and is freestanding separated from any substrate.
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26. An optically encoded particle consisting of:
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a first porous layer having a predetermined first porosity; and a plurality of n additional consecutive porous layers upon said first porous layer, said n additional consecutive porous layers having predetermined thicknesses and porosities and at least one of said n additional consecutive porous layers having a porosity differing from said first porosity and a receptor or targeting moiety within one or more of said first porous layer and said n additional consecutive porous layers;
whereinsaid first porous layer and said n additional porous layers are configured to produce an interference pattern in the reflectivity spectrum having a distinct series of peaks such that the interference pattern forms an optical signature having a particular predetermined code determined by the porosities and thicknesses of said first porous layer and said n additional porous layers, and wherein the particle has a diameter of a few hundred microns or less and is freestanding separated from any substrate.
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Specification