Cancer therapy

• US 8,765,729 B2
• Filed: 11/09/2006
• Issued: 07/01/2014
• Est. Priority Date: 01/19/2001
• Status: Expired due to Fees

• Current Assignee: Aeolus Sciences Incorporated, Duke University, National Jewish Medical and Research Center
• Original Assignee: Aeolus Sciences Incorporated, Duke University, National Jewish Medical and Research Center
• Inventors: Crapo, James D., Day, Brian J., Batinic-Haberle, Ines, Gammans, Richard, Vusjaskovic, Zeljko
• Primary Examiner(s): Wang, Shengjun
• Application Number:
  US11/558,408
• Publication Number:
  US 20070149498A1
• Time in Patent Office: 2,791 Days
• Field of Search: 514/183, 514/184, 514/185
• US Class Current: 514/185
• CPC Class Codes: A61K 31/409 having four such rings, e.g. porphine derivatives, bilirubin, biliverdine hemin, hematin A61K31/555
• CPC Class Codes: A61K 31/555 containing heavy metals, e.g. hemin, hematin, melarsoprol
• CPC Class Codes: A61K 41/00 Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants

Abstract

The present invention relates, in general, to cancer therapy, and, in particular, to a method of preventing or treating cancer using low molecular weight antioxidants (e.g., mimetics of superoxide dismutase (SOD)) as the active agent or as a chemo- and/or radio-protectant. The invention also relates to compounds and compositions suitable for use in such a method.

Claims

1. A method of treating lung cancer in a mammal, the method comprising:

administering to a mammal in need thereof a radiation therapy and a compound having the formula;

2. The method according to claim 1, wherein the mammal is a human.

3. A method of treating radiation-induced lung injury in a mammal in need thereof comprising administering to said mammal a compound having the formula:

4. The method according to claim 3, wherein the mammal is a human.