Azetidine compound and pharmaceutical use thereof

• US 8,765,739 B2
• Filed: 05/14/2010
• Issued: 07/01/2014
• Est. Priority Date: 05/14/2009
• Status: Active Grant

• Current Assignee: Japan Tobacco Inc.
• Original Assignee: Japan Tobacco Inc.
• Inventors: Ikegashira, Kazutaka, Ikenogami, Taku, Ogawa, Naoki, Matsumoto, Tatsuya, Oka, Takahiro, Matsuo, Takuya, Yamasaki, Takayuki
• Primary Examiner(s): BERNHARDT, EMILY A
• Application Number:
  US12/780,146
• Publication Number:
  US 20100331301A1
• Time in Patent Office: 1,509 Days
• Field of Search: None
• US Class Current: 514/218
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 401/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 405/14 containing three or more hetero rings
• CPC Class Codes: C07D 409/14 containing three or more hetero rings
• CPC Class Codes: C07D 413/14 containing three or more hetero rings

Abstract

Compounds of formula [I]:

wherein each symbol is as defined in the description,
or a pharmaceutically acceptable salts or solvates thereof.

Claims

1. A compound of formula [I]:

2. The compound according to claim 1:

wherein

R^b is

(1) C_1-6 alkyl group which is optionally substituted with the same or different 1 to 5 substituents selected from Group A,

(2) —

O—

(CH₂)_N1—

(O)_N2—

R^b1,

(3)

—

Y^c—

O—

R^b2

(4) —

CH═

CH—

C(═

O)—

R^b3,

(5) —

NR^b4R^b5, or

(6)

3. The compound of formula [II] according to claim 1:

4. The compound of formula [III] according to claim 1:

5. The compound of formula [II-C] according to claim 1:

6. The compound of formula [III-B] according to claim 1:

7. The compound of formula [IV-A] according to claim 1:

9. A pharmaceutical composition comprising the compound according to claim 1, or a pharmaceutically acceptable salt thereof, or a solvate of the compound or salt thereof, and a pharmaceutically acceptable carrier.

10. A method of treating rheumatoid arthritis in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of the compound according to claim 1, or a pharmaceutically acceptable salt thereof, or a solvate of the compound or salt thereof.

8. A compound having one of the formulas listed below, or a pharmaceutically acceptable salt thereof, or a solvate of the compound or salt thereof: