X-ray imaging with x-ray markers that provide adjunct information but preserve image quality

• US 8,768,026 B2
• Filed: 04/28/2008
• Issued: 07/01/2014
• Est. Priority Date: 11/26/2003
• Status: Active Grant

• Current Assignee: Hologic Incorporated
• Original Assignee: Hologic Incorporated
• Inventors: Ren, Baorui, Smith, Andrew P., Jing, Zhenxue, Stein, Jay A., DeFreitas, Kenneth F.
• Primary Examiner(s): Ton, Toan
• Assistant Examiner(s): CORBETT, JOHN M
• Application Number:
  US12/150,539
• Publication Number:
  US 20090268865A1
• Time in Patent Office: 2,255 Days
• Field of Search: 378 4- 27, 382128-132
• US Class Current: 382/131
• CPC Class Codes: A61B 5/1075 for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer A61B8/0858 takes precedence
• CPC Class Codes: A61B 6/0414 with compression means
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: A61B 6/544 dependent on patient size
• CPC Class Codes: A61B 6/583 using calibration phantoms

Abstract

A method and an apparatus for estimating a geometric thickness of a breast in mammography/tomosynthesis or in other x-ray procedures, by imaging markers that are in the path of x-rays passing through the imaged object. The markings can be selected to be visible or to be invisible when the composite markings/breast image is viewed in clinical settings. If desired, the contribution of the markers to the image can be removed through further processing. The resulting information can be used determining the geometric thickness of the body being x-rayed and thus setting imaging parameters that are thickness-related, and for other purposes. The method and apparatus also have application in other types of x-ray imaging.

Claims

1. A breast x-ray imaging method comprising:

concurrently x-ray imaging a first pattern of markers on or in a breast compression paddle and a patient'"'"'s breast immobilized between the paddle and an x-ray imaging receptor to thereby form a composite x-ray image in which both markers of the first pattern of markers and the breast are imaged, wherein an x-ray image of at least a part of the first pattern of markers is superimposed on an image of the breast in said composite x-ray image and some of the markers are above a noise level of their spatial environment;

computer-processing the composite x-ray image by (a) searching for image signals that are below a noise level of their spatial environment to thereby find locations in the composite x-ray image of markers of said first pattern of markers, and (b) removing contributions to the composite image of image markers at locations found in said searching but leaving, at said found locations, contributions of the breast that had been present at the found locations before said removing of marker contributions;

computer-processing information related to found locations of markers to derive geometric information regarding markers of the first pattern of markers imaged in said composite x-ray image;

computer-processing the geometric information to derive thickness information related to a thickness of the immobilized breast; and

using the thickness information for at least one of assessment of the imaged breast and further x-ray imaging of the breast.

2. A method as in claim 1 in which at least some of the imaged markers are visible in the composite image when viewed in clinical settings.

3. A method as in claim 1 in which the removing of contributions of markers comprises removing from the composite image essentially all contributions thereto of markers of the first pattern of markers included in said composite x-ray image.

4. A method as in claim 1 in which said first pattern of markers comprises two or more first patterns at different locations relative to said compression paddle, and said computer-processing further comprising deriving geometric information regarding imaged markers of each of said first patterns of markers and deriving thickness information related to a thickness of the breast at each of two or more different breast locations.

5. A method as in claim 4 including processing the information related to thickness of the breast at each of two or more different breast locations to derive information indicative of at least one of tilt and deformation of the compression paddle.

6. A method as in claim 5 including storing said information indicative of at least one of tilt and deformation in association with stored image information describing at least the imaged breast.

7. A method as in claim 1 in which said computer-processing to derive geometric information regarding imaged markers of the first pattern of markers comprises applying a correlation process to said composite x-ray image.

8. A method as in claim 7 including selecting a region of interest (ROI) in the x-ray image that is likely to contain at least a substantial portion of the imaged first pattern of markers and applying said correlation process only to the selected ROI.

9. A method as in claim 7 in which said correlation process comprises a shift-and-add process.

10. A method as in claim 1 including further computer-processing the image information to calculate density information characterizing the immobilized breast.

11. A method as in claim 10 including further computer-processing said density information to derive predictor information related to cancer risk.

12. A method as in claim 11 including recording said cancer predictor information in association with image information regarding the imaged breast.

13. A method as in claim 10 including recording said density information in association with image information regarding the imaged breast.

14. A method as in claim 10 including displaying said density information in association with a display of image information regarding the imaged breast.

15. A method as in claim 1 in which said first pattern of markers comprises spatially correlated markers.

16. A method as in claim 1 in which said x-ray imaging comprises acquiring a composite x-ray image formed of a number of projection composite x-ray images taken at different angles of an imaging x-ray beam relative to the breast, and said computer processing comprises deriving geometric information regarding markers of the first pattern of markers imaged in said projection x-ray images and computer-processing the geometric information to derive thickness information related to thickness of the immobilized breast, and processing information regarding the imaged breast from said projection images to derive information describing tomosynthesis slice image of the breast.

17. A method as in claim 1 including imaging a second pattern of markers concurrently with said imaging of the first pattern of markers such that said composite x-ray image further includes an image of markers of the second pattern of markings, said second pattern being at a second distance from the x-ray source that is different from the distance of said first pattern from the source, and wherein said computer-processing of the image information further comprises deriving second geometric information regarding the imaged markings of the second pattern of markings and deriving therefrom distance information related to said second distance.

18. A method as in claim 17 in which said second pattern of markings comprises two or more second patterns of markings that are at different locations.

19. A mammography/tomosynthesis apparatus comprising:

a breast immobilizer comprising a breast platform and a breast compression paddle with a first pattern of markers, said paddle and platform being configured to move toward each other to position a patient'"'"'s breast between the paddle and platform and flatten and immobilize the breast;

an x-ray source on one side of the immobilizer and an x-ray imaging receptor on the other side;

a control selectively energizing the x-ray source to emit an x-ray beam that traverses the paddle, the immobilized breast and the breast platform and impinges on the x-ray receptor, said receptor being configured to provide in response image information describing a composite x-ray image containing information regarding markers of the first pattern of markers imaged in said composite x-ray image and regarding the immobilized breast imaged in said image, wherein at least a portion of the imaged markers is superimposed on imaged breast tissue in said composite x-ray image and some of the imaged markers are above a noise level of their spatial environment;

a processor coupled with the x-ray receptor to receive from the receptor image information describing the composite x-ray image, said processor being configured to process the received image information to (a) search for image signals that are below noise levels in their spatial environment to thereby find locations in the composite x-ray image of markers of the first pattern, (b) derive geometric information regarding markers of the first pattern of markers imaged therein, (c) process the geometric information to derive thickness information related to thickness of the immobilized breast, and (d) remove contributions of markers from said composite x-ray image but leaving contributions of the breast that had been present at said found locations before said removing of marker contributions;

said processor further being configured to use the thickness information in at least one of (i) assessment of the breast imaged in the x-ray image and (ii) providing information related to parameters involved in controlling further x-ray imaging of the breast; and

a display selectively showing a display related to said x-ray image information.

20. An apparatus as in claim 19 in which said processor is configured to essentially all contributions of the imaged markers of the first pattern of markers from the composite image.

21. An apparatus as in claim 19 in which said first pattern of markers comprises two or more first sub-patterns of markers that are at different locations relative to said compression paddle.

22. An apparatus as in claim 21 in which said processor is further configured to derive geometric information regarding markers of each of said first sub-patterns of markers imaged in said x-ray image and to derive thickness information related to a thickness of the breast at each of two or more different breast locations.

23. An apparatus as in claim 22 in which said processor is further configured to process the information related to said thickness of the breast at each of two or more different breast locations to derive information indicative of tilt and/or deformation of the compression paddle.

24. An apparatus as in claim 23 in which said processor is further configured to store the information indicative of tilt and/or deformation together with stored breast imaging information.

25. An apparatus as in claim 21 in which said processor is further configured to select a region of interest (ROI) in the x-ray image that is likely to contain at least a substantial portion of the imaged markers of said first pattern of markers and to process only the image information related to the ROI in deriving geometric information regarding the imaged markers of the first pattern of markers.

26. An apparatus as in claim 19 in which said processor is further configured to process the breast image information to calculate density information characterizing the immobilized breast.

27. An apparatus as in claim 26 in which said processor is further configured to process said density information to derive predictor information related to cancer risk.

28. An apparatus as in claim 27 in which said processor is further configured to record said cancer predictor information in association with said breast image information.

29. An apparatus as in claim 26 in which said processor is further configured to record said density information in association with said breast image information.

30. An apparatus as in claim 26 in which said processor is further configured to cause said display to display said density information in association with a display of said breast image information.

31. An apparatus as in claim 19 in which at least some of the imaged markers of the first set of markers are visible when the composite x-ray image is viewed in clinical settings.

32. An apparatus as in claim 19 in which said first pattern of markers comprises two or more first sub-patterns of markers that are at different locations relative to said compression paddle.

33. An apparatus as in claim 32 in which said processor is further configured to derive geometric information regarding markers of each first sub-pattern of markers imaged in said x-ray image and to derive thickness information related to a thickness of the breast at each of two or more different breast locations.

34. An apparatus as in claim 19 in which said processor is further configured to select a region of interest (ROI) in the x-ray image that is likely to contain at least a substantial portion of the imaged markers of said first pattern of markers and to process only the image information related to the ROI in deriving geometric information regarding the imaged markers of the first pattern of markers.

35. An apparatus as in claim 19 in which said processor is further configured to process at least the breast image information in said composite x-ray image to calculate density information characterizing the immobilized breast.

36. An apparatus as in claim 35 in which said processor is further configured to process said density information to derive predictor information related to cancer risk.

37. An apparatus as in claim 36 in which said processor is further configured to record said cancer predictor information in association with at least breast image information contained in said composite x-ray image.

38. An apparatus as in claim 35 in which said processor is further configured to cause said display to display said density information in association with a display of breast image information contained in said composite x-ray image.

39. An apparatus as in claim 19 in which said processor is configured to apply a correlation process to said image information describing the composite x-ray image to derive said geometric information regarding imaged markers of said first pattern of markers.

40. An apparatus as in claim 19 including a component with a second pattern of markers situated between the x-ray source and an imaging plane of said x-ray receptor and wherein said composite x-ray image further contains information regarding markers of said second pattern of markers imaged in said image, and wherein said processor is further configured to process said information regarding imaged markers of said second pattern of markers to derive information regarding a position in space of said second pattern of markings.

41. An apparatus as in claim 40 in which said component is a magnification table between the breast and the breast platform, said magnification table having an upper surface with said second pattern of markings.

42. An apparatus as in claim 19 in which said apparatus comprises a tomosynthesis apparatus, said composite x-ray image comprises a plurality of tomosynthesis projection images at least one of which contains information regarding markers of the first pattern of markers imaged therein, said processor is configured to derive said geometric information from the at least one projection image that contains information regarding the markers and derive thickness information therefrom, and said processor is further configured to process the projection images to derive reconstructed slice images representing slices of the breast having selected orientations and thicknesses.

43. A method comprising:

x-ray imaging a first pattern of markers situated at a selected location relative to an object that is between an x-ray source and an imaging plane of an imaging x-ray receptor to thereby cause the receptor to form a composite x-ray image in which both markers of the first pattern of markers and the object are imaged, wherein at least a portion of the imaged markers is superimposed on an image of the object in said composite x-ray image and some of the imaged markers are above a noise level of their spatial environment;

computer-processing the x-ray image to derive geometric information regarding markers of the first pattern of markers imaged in said x-ray image, said processing comprising finding locations of imaged markers superimposed on the imaged breast in said composite image by searching for image signals that are below a noise level in their spatial environment, and removing marker contributions from such found locations but leaving at said location previously present contributions of the breast; and

using the geometric information to improve at least one of (a) further imaging of the object and (b) assessment of an image of the object.

44. A method as in claim 43 in which the using step comprises computer-processing the geometric information to derive thickness information related to a position in space of said first set of markings.

45. A method as in claim 44 in which the using step further comprises using the geometric information for co-registration of the x-ray image with other x-ray images.

46. A method as in claim 44 further comprising computer-processing the image information and said geometric information to remove essentially all contributions of markers of the first pattern of markers to the composite image.

47. A method as in claim 43 in which at least some of said markers imaged in said x-ray image are visible when viewing the image in clinical settings.

48. An x-ray apparatus comprising:

an x-ray source, an x-ray receptor, and an object support between the source and the receptor;

a control selectively energizing the source to emit an x-ray beam that passes through an object on said support and causes the receptor to provide an x-ray image of the object;

a first pattern of markers situated at a selected location in the path of said beam thereby causing said image to contain contributions of said markers, wherein at least at least a portion of the markers is imaged with said beam in superposition on the object in said x-ray image and some of the imaged markers are above a noise level of their spatial environment;

a processor configured to process the x-ray image to derive geometric information regarding said contributions of said markers, said processor further being configured to use the geometric information to improve at least one of (a) further imaging of the object and (b) assessment of an image of the object;

wherein said processing comprises finding locations of markers in said image through searching for image signals below noise levels in their environment and removing markers contributions from found locations but leaving at said locations pre-existing contributions of the object.

49. An x-ray apparatus as in claim 48 in which the processor is further configured to process the geometric information to derive spatial information related to the location in space of said first set of markings.

50. An x-ray apparatus as in claim 48 in which said processor is further configured to process information describing at least some of said x-ray image and to process said geometric information to remove essentially all contributions of markers of the first pattern of markers to the x-ray image.

51. A non-transitory computer readable medium encoded with a computer program, which program when implemented on a computer causes the computer to perform the steps of:

causing an x-ray imaging system to image a first pattern of markers situated at a selected location relative to an object that is between an x-ray source and an imaging plane of an imaging x-ray receptor to thereby cause the receptor to form a composite x-ray image in which both markers of the first pattern of markers and the object are imaged, wherein at least a portion of the imaged markers is superimposed on the image of the object in said composite image and some of the imaged markers are above a noise level of their spatial environment;

causing computer-processing of the x-ray image to derive geometric information regarding markers of the first pattern of markers imaged in said composite x-ray image, said processing comprising finding marker locations in said composite image through searching for image signals that are below noise levels in their environment and then removing marker contributions from such locations but leaving therein pre-existing contributions of the object; and

causing utilization of said geometric information.

52. The medium of claim 51, wherein said computer program when implemented on a computer further causes removal of essentially all contributions of said first pattern of markings from the composite image.