Multispot monitoring for use in optical coherence tomography
First Claim
1. An optical coherence tomography (OCT) system for determining an analyte level in tissue, comprising:
- a light source for generating skin-penetrating radiation suitable for OCT measurements;
a detector for receiving at least a portion of reflected light from the skin-penetrating radiation;
a beam scanner configured to direct a beam of radiation from the light source to a plurality of different locations on a two-dimensional region of a skin surface to scan a plurality of different tissue sites associated with each different location;
a processor configured to determine a subset of tissue sites that each include an analyte correlating region, wherein an analyte correlating region comprises a tissue site that is valid for measuring an analyte level; and
a controller configured to direct the beam scanner to monitor each of the subset of tissue sites determined to include analyte correlating regions, the controller further configured to exclude from monitoring at least a portion of tissue sites determined not to include analyte correlating regions.
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Accused Products
Abstract
Optical coherence tomography (herein “OCT”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue. For instance, if OCT is to be used to estimate the level of an analyte (e.g., glucose) in tissue, a measure of the extent of blood flow can potentially indicate the presence of an analyte correlating region, which would be suitable for analyte level estimation with OCT. Another aspect is related to systems and methods for scanning multiple regions. An optical beam is moved across the surface of the tissue in two distinct manners. The first can be a coarse scan, moving the beam to provide distinct scanning positions on the skin. The second can be a fine scan where the beam is applied for more detailed analysis.
967 Citations
22 Claims
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1. An optical coherence tomography (OCT) system for determining an analyte level in tissue, comprising:
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a light source for generating skin-penetrating radiation suitable for OCT measurements; a detector for receiving at least a portion of reflected light from the skin-penetrating radiation; a beam scanner configured to direct a beam of radiation from the light source to a plurality of different locations on a two-dimensional region of a skin surface to scan a plurality of different tissue sites associated with each different location; a processor configured to determine a subset of tissue sites that each include an analyte correlating region, wherein an analyte correlating region comprises a tissue site that is valid for measuring an analyte level; and a controller configured to direct the beam scanner to monitor each of the subset of tissue sites determined to include analyte correlating regions, the controller further configured to exclude from monitoring at least a portion of tissue sites determined not to include analyte correlating regions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification