Magnetic nanostructured propellers

• US 8,768,501 B2
• Filed: 04/29/2011
• Issued: 07/01/2014
• Est. Priority Date: 05/02/2010
• Status: Active Grant

• Current Assignee: Max-Planck-Gessellschaft Zur Forderung Der Wissenscaften E.V.
• Original Assignee: Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften e.V. (Max-Planck-Gesellschaft zur Frderung der Wissenschaften e)
• Inventors: Ghosh, Ambarish, Fischer, Peer
• Primary Examiner(s): Shechtman, Sean
• Assistant Examiner(s): GARLAND, STEVEN R
• Application Number:
  US13/098,126
• Publication Number:
  US 20110270434A1
• Time in Patent Office: 1,159 Days
• Field of Search: None
• US Class Current: 700/117
• CPC Class Codes: A61B 2017/00345 Micromachines, nanomachines, microsystems
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: B82Y 25/00 Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

Methods and systems for the fabrication and application of Magnetically Actuated Propellers (MAPs) are described. MAPs are structures with typical feature sizes in the range of 20 nanometers up to 100 microns in one spatial dimension. MAPs are propellers that can be obtained from nano-structured surfaces and that can be produced in large numbers. MAPs are propelled and controlled by magnetic fields. The MAPs are optimized for low Reynolds number propulsion and can be moved in fluids and biological tissues. MAPs are useful for measurements, quantification, imaging and sensing purposes e.g. detecting biomolecules and for the controlled transportation of (drug- and bio-) molecules and the delivery of microscopic and nanoscale objects and/or materials or systems of therapeutic value. The MAPs are formed on a substrate and the released from the substrate using sonication, vibration, agitation, dissolution or etching which allows the MAPs to be produced in large numbers.

Claims

1. A method for making magnetically actuated propellers (MAPs) configured to be moved by magnetic fields, the method comprising:

providing a vapor source and a substrate in a vacuum chamber;

rotating the substrate about an axis normal to a surface of the substrate at a rotation rate;

directing a vapor flux having a flux rate from the vapor source in a direction toward the surface of the substrate to deposit at least one material on the surface of the substrate, with the surface of the substrate being positioned at an angle theta that is different from zero with respect to the direction from which the vapor flux is directed toward the substrate;

monitoring the flux rate with a deposition-rate monitor to establish a deposition rate;

controlling the deposition rate, the rotation rate, and the angle with a controller;

governing the rotation rate and the angle to promote the growth of structures comprising at least one of a chiral structure, a helical structure, a propeller-like structure, and a screw-like structure; and

releasing the structures from the substrate using a method comprising at least one of sonication, vibration, agitation, dissolution, and etching.

2. The method of claim 1, further comprising:

providing at least one further vapor source to deposit at least one different material on the surface of the substrate, the at least one different material being selected from the group consisting of;

silicon, glass, and plastic materials.

3. The method of claim 1, further comprising:

patterning the substrate by a method comprising at least one of lithography, nanoimprint lithography, printing, depositing nanoparticles onto the surface, and depositing microparticles onto the surface.

4. The method of claim 1, further comprising:

depositing a magnetic material on the at least one material, where the depositing of the at least one material results in a structured surface with shapes that can be propelled at Reynolds numbers <

1 by a rotation about the structure'"'"'s long axis, and where said magnetic material is a ferromagnetic material.

5. The method of claim 1, wherein a magnetic material is subsequently added to the structures via a different deposition method comprising at least one of a surface functionalization method, chemical vapor deposition, thermal vapor deposition, sputtering, physical vapor deposition, and an electrochemical method.

6. The method of claim 1, wherein said MAPs are fabricated by evaporating material, with said material being magnetic, and wherein a non-magnetic material is subsequently added via a different deposition method comprising at least one of a surface functionalization method, chemical vapor deposition, thermal vapor deposition, sputtering, physical vapor deposition, and an electrochemical method.

7. The method of claim 1, wherein said MAPs are fabricated with a material comprising at least one of a magnetic material, a ferromagnetic material, and cobalt.

8. The method of claim 1, wherein said MAPs comprise a ferromagnetic material that is magnetized during or after fabrication.

9. The method of claim 1, wherein said MAPs are magnetically actuated in an environment comprising at least one of a fluid, a solution, a tissue, an organ, a gel, biological matter, a suspension, a cell, a cell culture, a plant, an animal, a human, soil, a solid, and a mixture, by the application of a magnetic field that comprises at least one of a homogenous magnetic field, a time-varying magnetic field, a magnetic field that changes its direction, and a magnetic field that has a gradient.

10. The method of claim 9, wherein said magnetic field used to actuate said MAPs changes in space to exert a torque on the MAPs, and where said magnetic field rotates in time and space and therefore causes the rotation of said MAPs, which due to their shape exhibit rotation-translation coupling and therefore translate through a medium in a desired direction.

11. The method of claim 9, wherein said magnetic field used to actuate the magnetic propellers is generated by manipulating permanent magnets.

12. The method of claim 9, wherein magnetic fields used to actuate the magnetic propellers are generated by passing current through an electric circuit comprising at least one of conductors, coils, Helmholtz coils, and Maxwell coils.

13. The method of claim 12, wherein said current is controlled by at least one of an electronic instrument, a computer, and a system with feedback control.

14. The method of claim 1, wherein at least one magnetically actuated propeller is used for at least one of:

delivery of drug molecules, a contrast agent in medical imaging, delivery of materials that aid medical diagnosis, and delivery of materials that have therapeutic value.

15. The method of claim 1, wherein said MAPs are used to determine and/or measure a property comprising at least one of a rheological property and a mechanical property, in a medium comprising at least one of a fluid, a solution, a tissue, an organ, a gel, biological matter, a suspension, a cell, a cell culture, a plant, an animal, a human, soil, a solid, and a mixture.

16. The method of claim 1, wherein said MAPs are not actively propelled, but their passive thermal motion is observed with the aid of a device comprising at least one of a camera, a microscope, and an imaging device, and wherein said passive thermal motion is used to determine a mechanical or a rheological property comprising at least one of flow speed, flow direction, viscosity, elasticity, viscoelasticity, diffusion constant, and concentration.

17. The method of claim 1, wherein said magnetic propellers are used for sensing comprising at least one of:

a pH level, an oxygen concentration, a sugar concentration, a gas concentration, a bio-molecule, a pathogen, a disease marker, a polynucleotide, a nucleic acid, a polypeptide, a protein, an antibody, a glycoprotein, a lipid, a carbohydrate, a fatty acid, a fatty ester, a macromolecular polypeptide complex, a vitamin, a virus, a bacterial cell, a virus infected cell, and a bacteria infected cell.

18. The method of claim 1, wherein said MAPs are coupled to a target comprising at least one of a biomolecule, a chemical, a pharmaceutical compound, a drug molecule, a nanoparticle, a quantum dot, a fluorescent molecule, an organic molecule, an inorganic molecule, and a part of the inorganic molecule, and wherein said MAPs are used to deliver said target to a desired location comprising at least one of a cell, a cell culture, a tissue, an organ, biological material, a fluid, a suspension, a liquid, a gel, a mixture, soil, inside a plant, inside an animal, inside a human, and inside a solid.

19. The method of claim 18, wherein said MAPs are used for an application used in at least one of biotechnology, veterinary medicine, diagnosis of human diseases, treatment of human diseases, and medicine.

20. The method of claim 18, wherein said biomolecule comprises at least one of a polynucleotide, a nucleic acid, a polypeptide, a protein, an antibody, a glycoprotein, a lipid, a carbohydrate, a fatty acid, a fatty ester, a macromolecular polypeptide complex, a vitamin, a virus, a bacterial cell, a virus infected cell, and a bacteria infected cell.

21. The method of claim 1, wherein at least one of said MAPs is employed to perform a task comprising at least one of entering, probing, and modifying, in a medium comprising at least one of a cell, a cell culture, a tissue, an organ, biological material, a fluid, a suspension, a liquid, a gel, a mixture, soil, a plant, an animal, a human, and a solid.

22. The method of claim 1, wherein said MAPs are made of at least one material that aids at least one of medical imaging, diagnosis, and medical therapy.

23. An apparatus for making magnetically actuated propellers (MAPs) configured to be moved by magnetic fields, comprising:

a vacuum chamber having at least one vapor source for generating a vapor flux, a substrate holder configured to hold a substrate onto which one or more materials from the at least one vapor source is deposited, and a means for controlling a deposition-rate of the vapor flux directed toward the substrate;

a process controller that controls a predetermined incidence angle theta formed by a direction of the vapor flux and a surface normal to the substrate, as well as a direction of rotation and a rotation speed of the substrate about an axis of the substrate during deposition, wherein the process controller is configured to adjust the rotation speed and the incidence angle in response to the deposition rate of the vapor flux, and the vapor flux is adjusted and the at least one source of the vapor flux is changed without breaking vacuum, the process controller being configured to generate commands to vary the incidence angle and the rotation speed during deposition so as to promote a growth of structures of a predetermined shape, and surface morphologies that, once removed from the substrate, permit propulsion of the structures in a medium by a magnetic field, the medium comprising at least one of a fluid, a solution, a tissue, an organ, a gel, biological matter, a cell, a cell culture, a suspension, soil, a plant, an animal, a human, a solid, and a mixture; and

separation means for releasing the structures from the substrate, the separation means being configured to use a method comprising at least one of;

sonication, vibration, agitation, dissolution, and etching.

24. The apparatus of claim 23, wherein the magnetically actuated propellers (MAPs) are fabricated by at least one of two-photon lithography, photolithography, interference lithography, stereolithography, lithographic techniques used for producing micro devices, focused ion beam etching, reactive ion etching, molecular beam epitaxy, chemical vapor deposition, emulsion polymerization, molding, laser cutting, printing, inkjet-printing, electrochemical deposition, physical vapor deposition, vacuum deposition, and Glancing Angle Deposition (GLAD).