Autosampler with control unit for performing a cleaning operation

• US 8,770,046 B2
• Filed: 09/01/2010
• Issued: 07/08/2014
• Est. Priority Date: 09/07/2009
• Status: Active Grant

• Current Assignee: Shimadzu Corporation
• Original Assignee: Shimadzu Corporation
• Inventors: Maeda, Yoshiaki, Nakamura, Takafumi, Yasunagi, Kenichi
• Primary Examiner(s): Williams, Hezron E
• Assistant Examiner(s): Huang, David Z
• Application Number:
  US13/382,499
• Publication Number:
  US 20120111127A1
• Time in Patent Office: 1,406 Days
• Field of Search: 738/63, 738/630.1, 738/642.1
• US Class Current: 73/863.01
• CPC Class Codes: G01N 2030/202 rotary valves
• CPC Class Codes: G01N 30/18 using a septum or microsyringe
• CPC Class Codes: G01N 30/20 using a sampling valve
• CPC Class Codes: G01N 30/24 Automatic injection systems
• CPC Class Codes: G01N 35/1097 characterised by the valves valves in general F16K

Abstract

An autosampler is provided with a needle, a measuring pump which sucks and discharges liquid through the needle, a movement mechanism for the needle, and an injection port which has a needle sealing surface. A sample liquid is sucked into the needle and then the sample liquid discharged with the tip of the needle pressed to the needle sealing surface. When cleaning the needle sealing surface, a cleaning liquid within the injection port is sucked and then the cleaning liquid is discharged and sucked into the injection port at a position at which the tip of the needle does not make contact with the needle sealing surface. Alternatively, after the cleaning liquid is discharged into the injection port, the needle may be caused to perform an up and down motion such that the tip of the needle contacts the needle sealing surface and then is lifted.

Claims

1. An autosampler comprising:

a needle whose tip is formed to be tapered;

a measuring-pump for discharging and drawing in by suction a liquid through said needle;

a movement mechanism for moving said needle in a horizontal direction and a vertical direction;

an injection port having a needle-sealing surface and connected to an analysis flow path via a valve; and

a control unit for controlling said measuring-pump and said movement mechanism,

wherein after a sample solution that is held in a sample vessel is drawn in by suction through said needle, the tip of said needle is pressed against said needle-sealing surface and said sample solution is discharged so that said sample solution is introduced into said analysis flow path through said injection port; and

said control unit performs a cleaning operation for cleaning said needle-sealing surface by causing said measuring-pump to draw in from a cleaning liquid vessel by suction, an amount of a cleaning liquid to be held within said injection port, then causing said needle to be moved to a position where the tip of said needle does not contact said needle-sealing surface and then causing said measuring-pump to cause a discharge and suction of the cleaning liquid into and from said injection port through said needle.

2. The autosampler according to claim 1 wherein said control unit causes said cleaning operation to be performed a plurality of times.

3. The autosampler according to claim 1 or 2 wherein said needle is lowered when a cleaning operation is performed by said control unit.

4. The autosampler according to claim 3 wherein, when said control unit performs a cleaning operation, an up-and-down motion of the needle involving lowering said needle to a position where the tip of said needle comes into contact with said needle-sealing surface and then raising said needle to a position where the tip of the needle is not in contact with said needle-sealing surface is performed once or a plurality of times during the time from the discharge of said cleaning liquid to the suction of said cleaning liquid by said measuring pump.

6. The autosampler according to claim 1 wherein said control unit cleans the interior of an analysis flow path by causing the tip of said needle to be pressed against said needle-sealing surface and causing said measuring-pump to discharge into and draw in by suction said cleaning liquid from said injection port through said needle.

5. An autosampler comprising:

a needle whose tip is formed to be tapered;

a measuring-pump for discharging and drawing in by suction a liquid through said needle;

a movement mechanism for moving said needle in a horizontal direction and a vertical direction;

an injection port having a needle-sealing surface and connected to an analysis flow path via a valve; and

a control unit for controlling said measuring-pump and said movement mechanism;

wherein after a sample solution that is held in a sample vessel is drawn in by suction through said needle, the tip of said needle is pressed against said needle-sealing surface and said sample solution is discharged so that said sample solution is introduced into said analysis flow path through said injection port; and

said control unit performs a cleaning operation for cleaning said needle-sealing surface by causing said measuring-pump to draw in from a cleaning liquid vessel by suction, an amount of a cleaning liquid to be held within said injection port, then causing said needle to be moved to a position where the tip of said needle does not contact said needle-sealing surface, then causing said measuring-pump to discharge said cleaning liquid, then raising said needle to a position where the tip of said needle is not in contact with the surface of the cleaning liquid that is held within said injection port, and then causing said measuring-pump to draw air in by suction and then discharge the air.