Capsule camera with variable illumination of the surrounding tissue

• US 8,771,176 B2
• Filed: 04/12/2007
• Issued: 07/08/2014
• Est. Priority Date: 07/24/2006
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Hendriks, Bernardus Hendrikus Wilhelmus, Kuhn, Michael Harald, Zaengel, Thomas, Van Der Vaart, Nijs Cornelis
• Primary Examiner(s): Smith, Philip R
• Assistant Examiner(s): CHOU, WILLIAM B
• Application Number:
  US12/374,506
• Publication Number:
  US 20090177033A1
• Time in Patent Office: 2,644 Days
• Field of Search: 600/109, 600/160, 600/167, 600/173, 600/177, 600/178, 359/665, 359/666
• US Class Current: 600/167
• CPC Class Codes: A61B 1/00087 Tools A61B17/00234 takes precedence
• CPC Class Codes: A61B 1/00165 with light-conductive means, e.g. fibre optics A61B1/07 takes precedence
• CPC Class Codes: A61B 1/00188 with focusing or zooming features
• CPC Class Codes: A61B 1/0019 characterised by variable lenses
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 1/042 characterised by a proximal camera, e.g. a CCD camera
• CPC Class Codes: A61B 1/043 for fluorescence imaging
• CPC Class Codes: A61B 1/0625 for multiple fixed illumination angles
• CPC Class Codes: A61B 1/0627 for variable illumination angles
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 2018/00482 Digestive system
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00589 Coagulation
• CPC Class Codes: A61B 2018/00642 with feedback, i.e. closed loop control
• CPC Class Codes: A61B 2018/00904 Automatic detection of target tissue
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61N 2005/0609 Stomach and/or esophagus
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/0603 : for treatment of body cavities
• CPC Class Codes: A61N 5/062 : Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: G03B 15/02 : Illuminating scene

Abstract

The application relates to an ingestible capsule and method for in vivo imaging and/or treatment of one or more diseased areas of interest within the gastrointestinal tract of an animal or human being. The capsule comprises an image sensor; a lens system for focusing images onto the image sensor; at least one light source for illumination of the tissue area of interest, the at least one light source optionally being capable of providing optical therapeutic treatment to the diseased areas; a variable lens system located in front of the at least one light source, wherein the variable lens system comprises beam steering means and focusing means for directing and focusing the light beams from the at least one light source onto the diseased tissue areas, —a control unit in communication with the image sensor, the at least one light source, and variable lens system, a power source for powering the image sensor, the at least one light source and the control unit; and a non-digestible, transparent outer protective shell configured to pass through the gastrointestinal tract, housing within the image sensor, the lens system, the at least one light source, the variable lens system, the control unit and the power source.

Claims

1. An ingestible untethered capsule for in vivo imaging and/or treatment of diseased tissue within a gastrointestinal tract of an animal or human being, said capsule comprising:

a camera including an image sensor and a first lens located in front of the image sensor for taking images of the diseased tissue;

at least one light source located laterally adjacent the image sensor for providing one or more light beams for illumination and optical therapeutic treatment of the diseased tissue;

a second lens located in front of the at least one light source for focusing at least one of the light beams from the at least one light source on a focus spot along a first path in a first direction onto the diseased tissue; and

a controller connected to the camera and the second lens and configured to correct for motion of the capsule by controlling the second lens to maintain the focus spot as the capsule moves within the gastrointestinal tract.

2. The ingestible capsule of claim 1, wherein the at least one light source includes first and second light source, the second light source providing optical therapeutic treatment to the diseased tissue.

3. The capsule of claim 2, wherein the first and second light sources comprise lasers.

4. The capsule of claim 1, wherein the second lens comprises a liquid lens system.

5. The capsule of claim 1, further comprising an outer protective shell, wherein the outer protective shell is non-digestible, transparent, and configured to pass through the gastrointestinal tract.

6. The capsule of claim 1, further comprising a power source for powering the image sensor, the at least one light source and the control unit.

7. The capsule of claim 1, wherein the controller further comprising a memory for storing images received from the image sensor as the capsule travels through the gastrointestinal tract and a transmitter for transfer the stored images, the controller is configured to control the at least one light source and the second lens and to correlate and transfer the stored images.

8. The capsule of claim 1, wherein the power source is externally driven with a magnetic signal to produce electrical power to enable continuous imaging and treatment of the diseased tissue.

9. The capsule of claim 1, further comprising

a detector located in front of the at least one light source configured to detect second light beams reflected from the diseased tissue in a second direction opposite the first direction along the first path;

and

a beam splitter configured to focus the light beams and the reflected second light beams on the detector through an aperture,

wherein to correct for motion of the capsule the controller correlates successive images of the focus spot and keeps the focus spot on the tissue area to be treated by changing settings of the second lens that is scanning the reflected light beams.

10. An ingestible untethered capsule for in vivo imaging and/or treatment diseased tissue within a gastrointestinal tract of animal or human being, said capsule comprising:

a camera including an image senor and first lens located in front of the image sensor for taking in images of the diseased tissue;

at least one light source located laterally adjacent the camera for providing one or more light beams for illumination and optical therapeutic treatment of the diseased tissue;

a second lens located in front of the at least one light source for focusing at least one of the light beams from the at least one light source on a focus spot along a first path in a first direction onto the diseased tissue; and

a detector located in front of the at least one light source for detecting second light beams reflected from the diseased tissue in a second direction opposite the first direction along the first path;

a beam splitter located in front of the detector and configured to focus the light beams and the reflected second light beams on the detector through an aperture; and

a controller connected to the camera, the second lens, and the beam splitter and configured to correct for motion of the capsule by changing settings of the second lens to maintain the focus spot, after reconstructing the images of the diseased tissue,

wherein the second lens is scanning the reflected light beams.