Device delivering medicines by transpalpebral electrophoresis

• US 8,771,256 B2
• Filed: 10/27/2010
• Issued: 07/08/2014
• Est. Priority Date: 10/12/2001
• Status: Expired due to Fees

• Current Assignee: EyeGate Pharma S.A.S. (Kiora Pharmaceuticals Incorporated)
• Original Assignee: EyeGate Pharma S.A.S. (Kiora Pharmaceuticals Incorporated)
• Inventors: Behar-Cohen, Francine, Roy, Pierre
• Primary Examiner(s): FLICK, JASON E
• Application Number:
  US12/913,065
• Publication Number:
  US 20110098632A1
• Time in Patent Office: 1,350 Days
• Field of Search: 604/20
• US Class Current: 604/521
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61N 1/0412 Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

The invention concerns a device for ocular application of an active principle (1) comprising a main electrode (2) including an insulating layer, an adhesive layer designed to bind the insulating layer to a conductive layer, characterized in that the main electrode comprises a zone (21, 22) designed to be urged into contact with an eyelid.

Claims

1. A method for ocular application of an active substance through iontophoresis, the method comprising:

disposing a main electrode on an eyelid of a patient;

disposing a return electrode on a tissue of the patient away from the eyelid;

disposing an insert between the eyelid and the eyeball, the insert comprising the active substance and being disposed between the main electrode and the eyeball; and

substantially closing the eyelid and applying an electrical current circulating between the main electrode and the return electrode thereby allowing the active substance to penetrate the sclera of an eyeball of the patient via the applied electrical current, wherein the active substance penetrates into the eyeball via iontophoresis.

2. A method according to claim 1, wherein the electrical current is a direct current (DC) having an amplitude between about 0.5 mA and about 10 mA.

3. A method according to claim 1, further comprising impregnating an absorbent foam layer within the main electrode with the active substance.