Medical devices with selective titanium oxide coatings

• US 8,771,343 B2
• Filed: 06/15/2007
• Issued: 07/08/2014
• Est. Priority Date: 06/29/2006
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Weber, Jan, Atanasoska, Liliana, Shippy, James Lee III, Parsonage, Edward E.
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): PRESTON, REBECCA STRASZHEIM
• Application Number:
  US11/763,770
• Publication Number:
  US 20080004691A1
• Time in Patent Office: 2,580 Days
• Field of Search: None
• US Class Current: 623/1.46
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2002/30322 differing in surface structures
• CPC Class Codes: A61F 2250/0026 differing in surface structures
• CPC Class Codes: A61F 2250/0056 differing in wettability, e.g. in hydrophilic or hydrophobic behaviours
• CPC Class Codes: A61F 2310/00616 Coating made of titanium oxide or hydroxides
• CPC Class Codes: A61F 2310/0097 Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: B05D 1/32 using means for protecting parts of a surface not to be coated, e.g. using stencils, resists

Abstract

Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface and an outer abluminal wall surface and defining a central lumen or passageway. The inner luminal wall surface and side wall surface of the bands and connectors forming transverse passageways through the elongated tubular structure can bear a coating of hydrophilic material and the outer abluminal wall surface of the tubular structure can bear a coating of hydrophobic material.

Claims

1. A medical device comprising:

an elongated tubular structure having an inner luminal wall surface, an outer abluminal wall surface, and side wall surfaces extending therebetween,

a first coating on at least one or more regions of the luminal wall surface and/or the side wall surfaces comprising a material comprising titanium (+y) oxide (−

x),

a second coating on at least one or more regions of the abluminal wall surface comprising the material comprising the titanium (+y) oxide (−

x),

the material in one of the first coating and the second coating being hydrophobic and the one of the first coating and the second coating being hydrophobic, and the material in another of the first coating and the second coating being hydrophilic and the other one of the first coating and the second coating being hydrophilic, and

a layer of organic compound over the first and second coatings.

2. The medical device of claim 1, wherein the first coating is hydrophilic and the second coating is hydrophobic.

3. The medical device of claim 2, wherein the first coating is superhydrophilic.

4. The medical device of claim 2, wherein the second coating further comprises a biomolecule and a polymer.

5. The medical device of claim 1, wherein the first coating is hydrophobic and the second coating is hydrophilic.

6. The medical device of claim 5, wherein the second coating is superhydrophilic.

7. The medical device of claim 1, wherein the first coating covers the luminal wall surface.

8. The medical device of claim 5 or claim 7, wherein the first coating further covers the side wall surfaces.

9. The medical device of claim 1, wherein the second coating covers the abluminal wall surface.

10. The medical device of claim 1, wherein the second coating further comprises a biomolecule.

11. The medical device of claim 1, wherein the first coating further comprises a biomolecule.

12. The medical device of claim 11, wherein the first coating further comprises a polymer.

13. The medical device of claim 1, wherein the first coating and the second coating comprise phosphorus.

14. The medical device of claim 1, wherein one of the first coating and the second coating is porous.

15. The medical device of claim 14, wherein another of the first coating and the second coating is smooth.

16. The medical device of claim 14 further comprising biomolecules in pores of the one of the first coating and the second coating.

17. The medical device of claim 1, wherein the material comprises a crystal.

18. The medical device of claim 1, wherein the material is photoactive.

19. The medical device of claim 1, wherein the material in a first selectable state is hydrophilic and the material in a second selectable state is hydrophobic.

20. The medical device of claim 19, wherein the material is selected between the first state and the second state by exposure to UV light.

21. The medical device of claim 19, wherein the material is selected between the first state and the second state by wet-rubbing.