Oligosaccharide composition for treating skin diseases

• US 8,771,674 B2
• Filed: 11/21/2011
• Issued: 07/08/2014
• Est. Priority Date: 11/23/2010
• Status: Active Grant

• Current Assignee: Societe des Produits Nestle SA (Nestle SA)
• Original Assignee: Nestec SA (Nestle SA)
• Inventors: Sprenger, Norbert
• Primary Examiner(s): Carlson, Karen Cochrane
• Assistant Examiner(s): MOSS, NATALIE M
• Application Number:
  US13/988,990
• Publication Number:
  US 20130251682A1
• Time in Patent Office: 960 Days
• Field of Search: 424/93.4, 435/325
• US Class Current: 424/93.4
• CPC Class Codes: A23L 33/21 Addition of substantially indigestible substances, e.g. dietary fibres
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/28 Oligosaccharides
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/7016 Disaccharides, e.g. lactose, lactulose lactobionic acid A61K31/7032
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 35/741 Probiotics probiotic yeast, e.g. saccharomyces A61K36/06
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: C12N 1/20 Bacteria; Culture media therefor

Abstract

The invention discloses a composition comprising at least one N-acetyl-lactosamine, at least one sialylated oligosaccharide and at least one fucosylated oligosaccharide, for use in the prevention and/or treatment of skin conditions and skin diseases. Preferably said composition is a starter infant formula. Said skin disease is in particular atopic dermatitis.

Claims

1. A method for the prevention and/or treatment of skin conditions and skin diseases comprising the step of administering a composition comprising at least one chemically synthesized N-acetyl-lactosamine, at least one sialylated oligosaccharide and at least one fucosylated oligosaccharide to an individual in need of same, the sialylated oligosaccharide comprising 3′

-sialyllactose and 6′

-sialyllactose, and a ratio of 3′

-sialyllactose to 6′

-sialyllactose being in the range between 5;

1 and 1;

2 on a weight basis.

2. The method according to claim 1, wherein the N-acetyl-lactosamine is selected from the group consisting of lacto-N-tetraose and lacto-N-neotetraose.

3. The method according to claim 1, wherein the fucosylated oligosaccharide is selected from the group consisting of 2′

-fucosyllactose, 3-fucosyllactose, difucosyllactose, lacto-N-fucopentaoses, lacto-N-difucohexaose I, fucosyllacto-N-hexaose, Difucosyllacto-N-hexaose I and Difucosyllacto-N-neohexaose II.

4. The method according to claim 1, wherein the composition comprises at least one probiotic bacterial strain.

5. The method according to claim 1, wherein the composition comprises at least one prebiotic.

6. The method according to claim 1, the composition is selected from the group consisting of a starter infant formula, an infant formula, a follow-on formula, a baby food formula, an infant cereals formula and a growing-up milk.

7. The method according to claim 1, wherein the individual is a healthy infants and healthy young children.

8. The method according to claim 1, wherein the composition is administered before and/or during a weaning period.

9. The method according to claim 1, wherein the individual has experienced at least one episode of the skin diseases.

10. The method according to claim 1, wherein the individual has experienced at least one episode of skin dehydration and/or skin rash, roughness and/or dryness.

11. The method according to claim 1, wherein the individual has experienced at least one episode of atopic dermatitis.

13. The method according to claim 11, wherein the composition is a supplement.

12. A method for the enhancement of the oral tolerance to allergens in an individual comprising the step of administering to the individual a composition comprising at least one N-acetyl lactosamine, at least one sialylated oligosaccharide and at least one fucosylated oligosaccharide, as a synthetic nutritional agent, the sialylated oligosaccharide comprising 3′

-sialyllactose and 6′

-sialyllactose, and a ratio of 3′

-sialyllactose to 6′

-sialyllactose being in the range between 5;

1 and 1;

2 on a weight basis.