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Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression

  • US 8,772,025 B2
  • Filed: 01/27/2011
  • Issued: 07/08/2014
  • Est. Priority Date: 07/12/2007
  • Status: Active Grant
First Claim
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1. A zinc finger DNA-binding domain, wherein the DNA-binding domain comprises four zinc finger recognition regions ordered F1 to F4 from N-terminus to C-terminus, and wherein F1, F2, F3, and F4 comprise the following amino acid sequences:

  • F1;

    QSSDLSR (SEQ ID NO;

         9);

    F2;

    TSGNLTR (SEQ ID NO;

         10);

    F3;

    RSDDLSK (SEQ ID NO;

         11); and

    F4;

    DRSALAR (SEQ ID NO;

         12).

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