Dyes having ratiometric fluorescence response for detecting metabolites
First Claim
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1. A fluorophore, wherein the fluorophore is selected from the group consisting of:
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Abstract
The presently disclosed subject matter provides thiol-reactive, environmentally sensitive fluorescent dyes, or fluorophores, which have an emission wavelength in the visible spectral region. When conjugated with a binding protein, the fluorophores exhibit a ratiometric response to one or more ligands or target analytes. The presently disclosed fluorophore-binding protein conjugates can be used to detect the presence of or amount of physiologically-important metabolites, such as glucose, fatty acids, and lactate, in biological samples.
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30 Claims
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1. A fluorophore, wherein the fluorophore is selected from the group consisting of:
- 2. A biosensor compound having the following formula:
- 29. A biosensor compound having the following formula:
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