Hybrid stent and method of making

• US 8,772,672 B2
• Filed: 07/06/2012
• Issued: 07/08/2014
• Est. Priority Date: 04/01/2002
• Status: Active Grant

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Prabhu, Santosh
• Primary Examiner(s): Evans, Geoffrey S
• Application Number:
  US13/543,422
• Publication Number:
  US 20120274001A1
• Time in Patent Office: 732 Days
• Field of Search: 219/121.67, 219/121.69, 219/121.72, 264/400, 427/2.25
• US Class Current: 219/121.72
• CPC Class Codes: A61F 2/04 Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts A61F2/18, A61F2/20 take precedence; devices, other than stent-grafts, providing patency to, or preventing collapsing of, tubular structures of the body other than stent-grafts, e.g. stents A61F2/82; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/852 Two or more distinct overlapping stents
• CPC Class Codes: A61F 2/89 the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61F 2250/0032 differing in radiographic density
• CPC Class Codes: A61F 2250/0063 Nested prosthetic parts
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61K 31/727 Heparin; Heparan
• CPC Class Codes: A61L 2300/236 Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 31/022 : Metals or alloys
• CPC Class Codes: A61L 31/048 : obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 : Macromolecular materials
• CPC Class Codes: A61L 31/16 : Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61L 31/18 : Materials at least partially X-ray or laser opaque
• CPC Class Codes: B23K 2103/42 : Plastics B23K2103/16 takes precedence
• CPC Class Codes: B23K 2103/50 : Inorganic material, e.g. metals, not provided for in B23K2103/02 – B23K2103/26
• CPC Class Codes: B23K 2103/54 : Glass
• CPC Class Codes: B23K 26/38 : by boring or cutting
• CPC Class Codes: B23K 26/402 : involving non-metallic material, e.g. isolators
• CPC Class Codes: B29C 41/08 : Coating a former, core or other substrate by spraying or fluidisation, e.g. spraying powder spray-up of reinforcing fibres B29C70/305
• CPC Class Codes: B29C 41/14 : Dipping a core B29C41/10 takes precedence
• CPC Class Codes: B29C 41/20 : incorporating preformed parts or layers, e.g. moulding inserts or for coating articles
• CPC Class Codes: B29C 41/22 : Making multilayered or multicoloured articles
• CPC Class Codes: B29C 65/16 : Laser beams
• CPC Class Codes: B29C 65/68 : using auxiliary shrinkable elements
• CPC Class Codes: B29K 2027/18 : PTFE, i.e. polytetrafluorethene , e.g. ePTFE, i.e. expanded polytetrafluorethene
• CPC Class Codes: B29L 2031/7534 : Cardiovascular protheses
• CPC Class Codes: Y10T 29/49906 : Metal deforming with nonmetallic bonding
• CPC Class Codes: Y10T 428/139 : Open-ended, self-supporting conduit, cylinder, or tube-type article
• CPC Class Codes: Y10T 428/1393 : Multilayer [continuous layer]

Abstract

A stent is formed by encasing or encapsulating metallic rings in an inner polymeric layer and an outer polymeric layer. At least one polymer link connects adjacent metallic rings. The stent is drug loaded with one or more therapeutic agent or drug, for example, to reduce the likelihood of the development of restenosis in the coronary arteries. The inner and outer polymeric materials can be of the same polymer or different polymer to achieve different results, such as enhancing flexibility and providing a stent that is visible under MRI, computer tomography and x-ray fluoroscopy.

Claims

1. A method of making a hybrid stent, comprising:

coating a mandrel with a first polymer to form a first polymeric tube;

mounting a plurality of unconnected metallic rings over the first polymeric tube;

applying a second polymeric material over the metallic rings and the first polymeric tube to form the stent;

selectively removing portions of the first polymeric tube and second polymeric tube to form polymeric links which connect adjacent metallic rings together; and

removing the stent from the mandrel.

2. The method of claim 1, wherein the first polymeric tube is formed by dip-coating the mandrel in a first polymeric material.

3. The method of claim 1, wherein the second polymeric material is applied to the rings and the first polymeric tube by dip-coating.

4. The method of claim 1, wherein the second polymeric material is sprayed onto the metallic rings and the first polymeric tube.

5. The method of claim 1, wherein the links for connecting adjacent metallic rings are formed by laser ablation of the first and second polymeric materials.

6. The method of claim 1, wherein a therapeutic drug is loaded into either or both of the first and second polymeric materials.