Heart segmentation in cardiac rest and stress imaging

• US 8,774,474 B2
• Filed: 02/09/2010
• Issued: 07/08/2014
• Est. Priority Date: 03/24/2009
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Wieczorek, Herfried K., Bippus, Rolf Dieter
• Primary Examiner(s): Tran, Phuoc
• Application Number:
  US13/203,515
• Publication Number:
  US 20120033864A1
• Time in Patent Office: 1,610 Days
• Field of Search: 382/107, 382/128, 382/131, 382/173, 128/922
• US Class Current: 382/128
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 6/00 Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment instruments measuring radiation intensity for application in the field of nuclear medicine, e.g. in vivo counting, G01T1/161; apparatus for taking X-ray photographs G03B42/02
• CPC Class Codes: A61B 6/03 Computed tomography [CT] echo-tomography A61B8/14
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/507 for determination of haemodynamic parameters, e.g. perfusion CT
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal
• CPC Class Codes: G06T 2207/10108 Single photon emission computed tomography [SPECT]
• CPC Class Codes: G06T 2207/30048 Heart; Cardiac
• CPC Class Codes: G06T 2207/30101 Blood vessel; Artery; Vein; Vascular
• CPC Class Codes: G06T 7/11 Region-based segmentation

Abstract

A patient (14), at rest, is injected with a first isotope tracer. After a first uptake period, the patient is stressed and injected with a second isotope tracer. After a second isotope tracer uptake period, first and second isotope imaging data are concurrently detected by data acquiring devices (16). The first and second isotope imaging data are reconstructed into a first or rest state image, a second or stressed state image, and optionally a combined first and second isotope image. The image with the better image statistics is segmented to generate segmentation parameters, which segmentation parameters are applied to both the first or rest and second or stressed state images. In this manner, an image whose image statistics may be too weak for accurate segmentation is accurately segmented by generating two inherently aligned images and applying the same segmentation parameters to both.

Claims

1. A method of imaging comprising:

in a single imaging session, concurrently acquiring first isotope imaging data from a first isotope tracer uptaken by a subject in a first state and first and second isotope data from the first isotope tracer and a second isotope tracer uptaken by the subject in a subsequent second state;

reconstructing the acquired imaging data to generate a first state image from the first isotope imaging data and a second state image from the second isotope imaging data;

segmenting, based on the image with better noise statistics, one of the first or second state images or a combined image reconstructed from both the first and second isotope imaging data to generate segmentation parameters;

applying the segmentation parameters to both of the first state image and the second state image; and

concurrently displaying the segmented first and second state images.

2. The method according to claim 1, further including prior to performing the concurrent acquiring step in the single imaging session:

injecting the first isotope tracer into the subject to be imaged;

waiting for a first isotope tracer uptake period;

after the first isotope tracer uptake period and with an imaging session, injecting the second isotope tracer into the subject; and

,

waiting a second isotope tracer uptake period.

3. The method according to claim 2, wherein:

waiting for the first isotope tracer uptake period is performed with the subject in a rest state; and

waiting for the second isotope tracer uptake period is performed while the subject is in a stressed state.

4. The method according to claim 1, further including:

overlaying the segmented first and second isotope images in the display.

5. The method according to claim 1, wherein one of the first and second isotope tracers includes technetium (Tc) and the other of the first and second isotope tracers includes thallium (Tl).

7. The method according to claim 1, further including:

finding the heart of the subject in the one of the state images with the better image statistics or the combined image;

based on the image with better image statistics, reorienting the first and second state images such that main axes of the heart are oriented in preselected directions.

8. An imaging system comprising:

a gantry which defines an imaging region;

one or more imaging data acquiring devices disposed around the imaging region to acquire the first and second isotope imaging data;

one or more processors programmed to perform the method according to claim 1;

a display which concurrently displays the first and second state images.

6. A method of imaging, comprising:

concurrently acquiring first and second isotope imaging data from a first isotope tracer uptaken by a subject in a first state and a second isotope tracer uptaken by the subject in a second state;

reconstructing the acquired imaging data to generate a first state image from the first isotope imaging data and a second state image from the second isotope imaging data;

segmenting a one of the first or second state images which has better image statistics or a combined image reconstructed from both the first and second isotope imaging data to generate segmentation parameters;

applying the segmentation parameters to each of the first state image and the second state image;

concurrently displaying the segmented first and second state images;

applying a physiological or cardiac gating during the concurrent acquiring of the first and second isotope imaging data; and

motion correcting each of the first isotope imaging data and the second imaging data in accordance with the gating.

9. A non-transitory computer-readable medium carrying software for controlling a computer processor to perform the steps of:

reconstructing concurrently acquired energy imaging data into a first state image depicting an uptake of a first isotope tracer injected into a subject and second imaging data into a second state image depicting an uptake of a second isotope tracer injected into the subject after both a first isotope tracer uptake period after injecting the first isotope tracer and a second isotope tracer uptake period after injection of the second isotope tracer, the concurrently acquiring being performed in a single imaging;

segmenting a one of the first and second state images which has better image statistics or an image reconstructed from both the first and second imaging data to generate segmentation parameters; and

applying the segmentation parameters to each of the first state image and the second state image.

10. An imaging system comprising:

a reconstruction processor that reconstructs concurrently acquired

first isotope imaging data into a first state image depicting an uptake of a first isotope tracer injected into a subject, and

second isotope imaging data into a second state image depicting an uptake of a second isotope tracer injected into the subject a first isotope tracer uptake period after injecting the first isotope tracer and a second isotope tracer uptake period before the concurrently acquiring of the first and second isotope imaging data, all of the reconstructed data being acquired in a single imaging session subsequent to the first and second isotope uptake periods;

a segmenting processor that segments, based on the image with better noise statistics, one of the first and second state images or an image reconstructed from both the first and second isotope imaging data to generate segmentation parameters;

an image adjustment processor that applies the segmentation parameters to each of the first state image and the second state image to generate a segmented first state image and a segmented second state image; and

a display which concurrently displays the segmented first and second state images.

11. The diagnostic imaging system according to claim 10, further including:

an image processor that overlays the segmented first and second images.

12. The diagnostic imaging system according to claim 10, wherein one of the first and second isotopes is technetium (Tc) and the other of the first and second isotopes is thallium (Tl).

14. The diagnostic imaging system according to claim 10, further including:

a processor that finds the heart in the one of the isotope images with the better image statistics or the combined isotope image;

a reorientation processor that concurrently reorients the first and second isotope images such that main axes of the heart are oriented in preselected directions.

13. A diagnostic imaging system, comprising:

a reconstruction processor that reconstructs concurrently acquired first energy imaging data into a first image depicting an uptake of a first isotope tracer injected into a subject and second energy imaging data into a second image depicting an uptake of a second isotope tracer injected into the subject a first isotope tracer uptake period after injecting the first isotope tracer and a second isotope tracer uptake period before the concurrently acquiring of the first and second energy imaging data;

a segmenting processor that segments a one of the first and second images which has better image statistics or an image reconstructed from both the first and second energy imaging data to generate segmentation parameters;

an image adjustment processor that applies the segmentation parameters to each of the first isotope image and the second image to generate a segmented first isotope image and a segmented isotope image;

a display which concurrently displays the segmented first and second images; and

a motion correction processor or the reconstruction processor that utilizes motion estimates to correct for motion in each of the first energy imaging data and the second energy imaging data in accordance with cardiac or physiological gating applied during the concurrent acquisition of the first and second energy imaging data.