Combination of tonic and burst stimulations to treat neurological disorders

• US 8,774,927 B2
• Filed: 01/28/2013
• Issued: 07/08/2014
• Est. Priority Date: 04/24/2007
• Status: Active Grant

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories)
• Inventors: DeRidder, Dirk
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Stice, Paula J
• Application Number:
  US13/751,998
• Publication Number:
  US 20130138179A1
• Time in Patent Office: 526 Days
• Field of Search: 607 46- 46, 607/58, 607/66, 607 68- 74
• US Class Current: 607/46
• CPC Class Codes: A61N 1/00 Electrotherapy; Circuits therefor A61N2/00 takes precedence; irradiation apparatus A61N5/00
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36096 Mood disorders, e.g. depression, anxiety or panic disorder
• CPC Class Codes: A61N 1/361 Phantom sensations, e.g. tinnitus
• CPC Class Codes: A61N 1/36178 Burst or pulse train parameters
• CPC Class Codes: A61N 1/37229 Shape or location of the implanted or external antenna
• CPC Class Codes: A61N 1/37264 Changing the program; Upgrading firmware
• CPC Class Codes: G16H 20/30 relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• CPC Class Codes: H04R 25/75 Electric tinnitus maskers providing an auditory perception

Abstract

The present application relates to a new stimulation design which can be utilized to treat neurological conditions. The stimulation system produces a combination of burst and tonic stimulation which alters the neuronal activity of the predetermined site, thereby treating the neurological condition or disorder.

Claims

1. A method of stimulating nerve tissue of a patient using an implantable pulse generator, the method comprising:

storing, in the implantable pulse generator, one or more first stimulation parameters that define a first stimulation program for tonic stimulation using electrical pulses, wherein the first stimulation program is adapted, by itself, to treat a sensory disorder of the patient;

storing, in the implantable pulse generator, one or more second stimulation parameters that define a second stimulation program for burst stimulation using a plurality of bursts of multiple electrical pulses wherein (i) the second stimulation program is substantially quiescent between the plurality of bursts of multiple electrical pulses and (ii) each of the plurality of bursts of multiple electrical pulses exhibits an inter-pulse interval of 0.005 seconds or less;

generating, by the implantable pulse generator, a combination of burst stimulation and tonic stimulation according to the first and second stimulation programs by repeating the first and second stimulation programs in cycles;

providing the burst and tonic stimulation from the implantable pulse generator to a stimulation lead; and

applying the burst and tonic stimulation to nerve tissue of the patient via one or more electrodes of the stimulation lead to treat the sensory disorder of the patient, wherein the combination of burst and tonic stimulation provides a reduced level of at least one side effect in the patient compared to tonic stimulation according to the first stimulation program by itself.

2. The method of claim 1, wherein the burst and tonic stimulation are applied to nerve tissue of the patient using different electrode combinations.

3. The method of claim 1, wherein the generating generates a respective pulse for the tonic stimulation immediately before beginning pulses for an individual burst of the burst stimulation.

4. The method of claim 1, further wherein pulses for the tonic stimulation are generated between an occurrence of a first pulse of a respective burst and a last burst of the respective burst of the burst stimulation.

5. The method of claim 1, wherein the sensory disorder is tinnitus or pain.