System and method for sensor recalibration

• US 8,777,852 B2
• Filed: 08/22/2007
• Issued: 07/15/2014
• Est. Priority Date: 12/30/2003
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Zhang, Yanan, Wang, Lu, Shah, Rajiv
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): TOTH, KAREN E
• Application Number:
  US11/843,601
• Publication Number:
  US 20080039822A1
• Time in Patent Office: 2,519 Days
• Field of Search: 600/345, 600/347, 600/365
• US Class Current: 600/365
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/4839 combined with drug delivery

Abstract

An implantable sensing system that includes a sensor for sensing a biological parameter, a processor connected to the sensor for processing the parameter and a drug delivery unit connected to the processor for responding to the processor based on the parameter. The processor is programmed to adjust an output of the sensor by compiling an array of data relating to the sensor, adjusting a sensor parameter a first time based on data in the array, adjusting a curve representing the sensor output based on data in the array and adjusting the sensor parameter a second time based on data in the array.

Claims

1. An implantable sensing system comprising:

a sensor for sensing a biological parameter;

a processor connected to the sensor for processing the parameter; and

a drug delivery unit connected to the processor for responding to the processor based on the parameter;

wherein the processor is programmed to adjust an output of the sensor by;

adjusting a calibration curve, wherein the adjusting of the calibration curve includes;

compiling an array of data relating to the sensor;

adjusting a sensor parameter, wherein the sensor parameter affects the calibration curve, a first time based on data in the array, whereby the calibration curve is adjusted a first time;

adjusting the shape of the calibration curve, whereby the calibration curve is adjusted a second time; and

after adjusting the shape of the calibration curve, adjusting the sensor parameter a second time based on the data in the array, whereby the calibration curve is adjusted a third time; and

calculating an adjusted sensor output based on the adjusted calibration curve, wherein the calculating of the adjusted sensor output is performed only after the calibration curve has been adjusted a third time.

2. The system of claim 1, wherein the sensor is a glucose sensor.

3. The system of claim 1, wherein the drug delivery unit is an insulin pump.

4. The system of claim 3, wherein the insulin pump delivers insulin in response to the adjusted sensor output.

5. The system of claim 1, wherein compiling an array comprises compiling blood glucose readings from a blood glucose meter.

6. The system of claim 1, wherein the array of data comprises glucose electrode readings and oxygen electrode readings, and wherein the adjusting the sensor parameter a first time includes adjusting the sensor parameter based on both the glucose electrode readings and the oxygen electrode readings.

7. The system of claim 1, wherein the sensor parameter is a nominal glucose current of the calibration curve.

8. The system of claim 7, wherein the nominal glucose current is adjusted by calculating a mean shift.

9. The system of claim 7, wherein the processor is further programmed to adjust the output of the sensor by:

calculating the nominal glucose current prior to adjusting the nominal glucose current a first time.

10. The system of claim 1, wherein adjusting the shape of the calibration curve representing the sensor output comprises performing a linear regression on the data in the array.

11. The system of claim 1, wherein adjusting the shape of the calibration curve representing the sensor output comprises adjusting the calibration curve in a piecewise linear fashion.

12. The system of claim 11, wherein the number of pieces in the piecewise linear adjustment is five.

13. The system of claim 1, wherein adjusting the shape of the calibration curve further comprises:

performing a linear regression on data in the array and wherein a result of the linear regression determines a first calibration point.

14. The system of claim 1, wherein the array of data includes time, independently measured glucose points, measured blood glucose concentrations, glucose electrode readings, and oxygen electrode readings.

15. The system of claim 14, wherein adjusting the sensor parameter a first time uses data for time, independently measured glucose points, measured blood glucose concentrations, glucose electrode readings and oxygen electrode readings.

16. The system of claim 1, wherein the array of data relating to the sensor includes readings taken from a blood glucose meter and corresponding sensor data.

17. The system of claim 16, wherein the readings taken from the blood glucose meter include measured blood glucose points and measured blood glucose readings and the corresponding sensor data includes glucose electrode readings and oxygen electrode readings.

18. The system of claim 1, wherein the processor is further programmed to adjust the output of the sensor by:

generating a calibration curve prior to adjusting the sensor parameter a first time.

19. An implantable sensing system comprising:

a sensor for sensing a biological parameter;

a processor connected to the sensor for processing the parameter; and

a drug delivery unit connected to the processor for responding to the processor based on the parameter;

wherein the processor is programmed to adjust an output of the sensor by;

adjusting a calibration curve, wherein the adjusting of the calibration curve includes;

compiling an array of data relating to the sensor;

generating a calibration curve;

adjusting a nominal output current of the calibration curve, wherein the nominal output current affects the calibration curve, a first time based on data in the array, whereby the calibration curve is adjusted a first time;

adjusting the shape of the calibration curve, whereby the calibration curve is adjusted a second time, wherein the adjusting the shape of the calibration curve includes performing a linear regression on data in the array and wherein a result of the linear regression determines a first calibration point;

after adjusting the shape of the calibration curve, adjusting the nominal output current a second time based on the data in the array, whereby the calibration curve is adjusted a third time; and

calculating an adjusted sensor output based on the adjusted calibration curve, wherein the calculating of the adjusted sensor output is performed only after the calibration curve has been adjusted a third time.