Apparatus and method for administering a therapeutic agent into tissue

• US 8,777,889 B2
• Filed: 08/01/2005
• Issued: 07/15/2014
• Est. Priority Date: 06/15/2004
• Status: Active Grant

• Current Assignee: ActiveO, Inc.
• Original Assignee: Ceramatec, Inc.
• Inventors: Steppan, James, Murphy, Kieran P, Joshi, Ashok V, Nachlas, Jesse A
• Primary Examiner(s): Berdichevsky, Aarti B
• Assistant Examiner(s): SCHELL, LAURA C
• Application Number:
  US11/193,339
• Publication Number:
  US 20070025890A1
• Time in Patent Office: 3,270 Days
• Field of Search: 604/181, 604/184, 604/187, 604 23- 26, 604/890.1, 604/891.1, 604143-147, 128/202.25, 422/186.07, 422/186.12
• US Class Current: 604/25
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61B 2017/00261 Discectomy
• CPC Class Codes: A61M 2005/006 for gases, e.g. CO2
• CPC Class Codes: A61M 2005/3132 having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
• CPC Class Codes: A61M 2202/0216 Ozone
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 5/286 upon internal pressure increase, e.g. pierced or burst A61M5/283 takes precedence
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: C01B 13/02 Preparation of oxygen by liquefying F25J
• CPC Class Codes: C01B 13/10 Preparation of ozone
• CPC Class Codes: C25B 1/13 Ozone

Abstract

An apparatus for administering a therapeutic is provided. In various embodiments, the apparatus includes a syringe having a barrel and a plunger and having an ozone generator associated therewith. The generator is initiated and a therapeutic gas is accumulated within the barrel, at which point it can be delivered from the barrel into a target site via a needle, thereby delivering therapeutic effects to that target site.

Claims

1. A syringe comprising:

a barrel;

a plunger having a nozzle end for insertion into a first end of said barrel and an actuator end to extend out of the barrel, wherein the plunger is configured to facilitate delivering an oxidizing gas from a second end of said barrel;

a corona-discharge device within said barrel for producing said oxidizing gas, wherein said corona-discharge device comprises a housing mounted to the plunger, between the nozzle end and the actuator end of the plunger, wherein the housing is configured to expel said oxidizing gas exclusively through the nozzle end of the plunger into a space formed within the barrel, between the nozzle end of the plunger and the second end of the barrel, and to prevent the oxidizing gas from occupying a space within the plunger between the housing and the actuator end of the plunger;

an accumulator chamber defined within said barrel holding oxygen and having an accumulation configuration in communication with said generator for producing said oxidizing gas from said oxygen when said accumulator chamber is in said accumulation configuration; and

said accumulator chamber having a delivery configuration for expressing said oxidizing gas from said second end when a desired level of oxidizing gas has been generated in said accumulator chamber.

2. The syringe of claim 1, further comprising a power supply located external to the syringe.

3. The syringe of claim 1, further comprising a power supply located within the plunger between the first and second end of the plunger.

4. The syringe of claim 1, further comprising a power supply located within the barrel between the first and second end of the barrel.

5. The syringe of claim 1, further comprising a power supply located on the exterior surface of the syringe.

6. The syringe of claim 1, further comprising a power supply that is connectible to the syringe at the time of ozone generation.