Poxviral oncolytic vectors
First Claim
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1. An oncolytic poxvirus comprising a defective I4L and/or F4L gene and a defective J2R gene, wherein the poxvirus further comprises a suicide gene with the proviso that said poxvirus is not NYVAC.
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Abstract
A poxvirus other than NYVAC but comprising a defective F4L and/or I4L gene and compositions comprising such poxvirus are useful for therapeutic purposes, and more particularly for the treatment of cancer.
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Citations
29 Claims
- 1. An oncolytic poxvirus comprising a defective I4L and/or F4L gene and a defective J2R gene, wherein the poxvirus further comprises a suicide gene with the proviso that said poxvirus is not NYVAC.
Specification