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Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating

  • US 8,778,376 B2
  • Filed: 06/09/2006
  • Issued: 07/15/2014
  • Est. Priority Date: 06/09/2006
  • Status: Expired due to Fees
First Claim
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1. A block copolymer comprising an elastin pentapeptide block (A) and a hydrophilic block (B),wherein the elastin pentapeptide is VGVPG (SEQ ID NO:

  • 1),wherein the A and B blocks are linked by a biodegradable polymer linkage;

    wherein block B comprises a synthetic polymer selected from polyethylene glycol (PEG), PVP (poly vinylpyrrolidinone), polyacrylamide, poly(PEG acrylate), poly (HEMA), poly(acrylic acid) or combinations of these; and

    wherein the synthetic polymer comprises phosphoryl choline (PC) pendant groups.

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