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Human growth hormone modified at position 35

  • US 8,778,880 B2
  • Filed: 01/28/2005
  • Issued: 07/15/2014
  • Est. Priority Date: 02/02/2004
  • Status: Expired due to Fees
First Claim
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1. A human growth hormone (hGH) polypeptide comprising an amino acid sequence of SEQ ID NO:

  • 2, wherein said hGH polypeptide comprises one or more polyethylene glycol moieties wherein the molecular weight of said polyethylene glycol is in a range of 10 k-40 k Dalton and wherein at least one polyethylene glycol moiety is attached to a para-acetyl-phenylalanine that is ribosomally incorporated into the hGH polypeptide at position 35 of SEQ ID NO;

    2 and wherein the hGH polypeptide has a serum half-life at least three-fold greater than the serum half-life of an unmodified hGH polypeptide.

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