Methods of administering pirfenidone therapy
DC CAFCFirst Claim
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1. An improved method of administering pirfenidone therapy to treat a patient suffering from a fibrotic disorder, inflammatory disorder, or autoimmune disorder comprising reducing the dosage of pirfenidone administered to the patient by about one-half to about one-third during concomitant administration of ciprofloxacin at a dose of 750 mg twice daily (1500 mg/day).
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Abstract
The disclosure relates to improved methods of administering pirfenidone therapy when ciprofloxacin is administered concomitantly.
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18 Claims
- 1. An improved method of administering pirfenidone therapy to treat a patient suffering from a fibrotic disorder, inflammatory disorder, or autoimmune disorder comprising reducing the dosage of pirfenidone administered to the patient by about one-half to about one-third during concomitant administration of ciprofloxacin at a dose of 750 mg twice daily (1500 mg/day).
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2. A method of administering pirfenidone therapy to treat a patient suffering from a fibrotic disorder, inflammatory disorder, or autoimmune disorder, comprising administering to the patient a therapeutically effective amount of pirfenidone, and avoiding concomitant administration of ciprofloxacin at a dose of 750 mg.
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13. An improved method of administering pirfenidone therapy to treat a patient comprising reducing the dosage of pirfenidone administered to the patient by about one-half to about one-third during concomitant administration of ciprofloxacin at a dose of 750 mg twice daily (1500 mg/day), wherein the patient suffers from a disease selected from idiopathic pulmonary fibrosis, pulmonary fibrosis, bronchiolitis obliterans, chronic lung transplant rejection, scleroderma, primary focal segmental glomerulosclerosis (FSGC) or membranoproliferative glomerulonephritis (MPGN), idiopathic interstitial pneumonia, interstitial lung disease in systemic sclerosis, a fibrosis condition of the lung, autoimmune lung diseases, benign prostate hypertrophy, coronary or myocardial infarction, atrial fibrillation, cerebral infarction, myocardiac fibrosis, musculoskeletal fibrosis, post-surgical adhesions, liver cirrhosis, renal fibrotic disease, fibrotic vascular disease, Hermansky-Pudlak syndrome, neurofibromatosis, diabetic retinopathy, skin lesions, lymph node fibrosis associated with HIV, chronic obstructive pulmonary disease (COPD), inflammatory pulmonary fibrosis, rheumatoid arthritis;
- rheumatoid spondylitis;
osteoarthritis;
gout;
sepsis;
septic shock;
endotoxic shock;
gram-negative sepsis;
toxic shock syndrome;
myofacial pain syndrome (MPS);
Shigellosis;
asthma;
adult respiratory distress syndrome;
inflammatory bowel disease;
Crohn'"'"'s disease;
psoriasis;
eczema;
ulcerative colitis;
glomerular nephritis;
chronic thyroiditis;
Grave'"'"'s disease;
Ormond'"'"'s disease;
autoimmune gastritis;
myasthenia gravis;
autoimmune hemolytic anemia;
autoimmune neutropenia;
thrombocytopenia;
pancreatic fibrosis;
chronic active hepatitis, hepatic fibrosis;
acute or chronic renal disease;
renal fibrosis;
diabetic nephropathy;
irritable bowel syndrome;
pyresis;
restenosis;
cerebral malaria;
stroke or ischemic injury;
neural trauma;
Huntington'"'"'s disease;
Parkinson'"'"'s disease;
acute or chronic pain;
allergic rhinitis, allergic conjunctivitis;
cardiac hypertrophy, chronic heart failure;
acute coronary syndrome;
cachexia;
malaria;
leprosy;
leishmaniasis;
Lyme disease;
Reiter'"'"'s syndrome;
acute synoviitis;
muscle degeneration, bursitis;
tendonitis;
tenosynoviitis;
herniated, ruptured, or prolapsed intervertebral disk syndrome;
osteopetrosis;
thrombosis;
silicosis;
pulmonary sarcosis;
bone resorption diseases, osteoporosis, multiple myeloma-related bone disorders;
metastatic breast carcinoma, colorectal carcinoma, graft-versus-host reaction;
multiple sclerosis, lupus, fibromyalgia;
AIDS, viral diseases, Herpes Zoster, Herpes Simplex I or II, influenza virus, Severe Acute Respiratory Syndrome (SARS) cytomegalovirus;
diabetes mellitus, acute myelogenous leukemia, chronic myelogenous leukemia, Kaposi'"'"'s sarcoma, metastatic melanoma, multiple myeloma, breast cancer, colorectal carcinoma;
gastric cancer;
non-small cell lung cancer (NSCLC);
bone metastases;
neuromuscular pain, headache, cancer pain, dental pain, or arthritis pain;
solid tumor angiogenesis, ocular neovascularization, infantile hemangioma;
organ hypoxia;
thrombin-induced platelet aggregation;
or protozoal diseases. - View Dependent Claims (18)
- rheumatoid spondylitis;
Specification