Glutamate agents in the treatment of mental disorders

• US 8,778,979 B2
• Filed: 04/05/2006
• Issued: 07/15/2014
• Est. Priority Date: 04/05/2005
• Status: Active Grant

• Current Assignee: Yale University
• Original Assignee: Yale University
• Inventors: Coric, Vladimir, Krystal, John H., Sanacora, Gerard
• Primary Examiner(s): CLAYTOR, DEIRDRE RENEE
• Application Number:
  US11/399,188
• Publication Number:
  US 20060270647A1
• Time in Patent Office: 3,023 Days
• Field of Search: 514/360, 514/367
• US Class Current: 514/360
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/13 Amines A61K31/04 takes precedence
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/425 Thiazoles
• CPC Class Codes: A61K 31/428 condensed with carbocyclic rings
• CPC Class Codes: A61K 31/43 Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61K 31/545 Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins, cefaclor, or cephalexine
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: G02B 1/10 Optical coatings produced by application to, or surface treatment of, optical elements G02B1/08 takes precedence
• CPC Class Codes: G02B 5/281 designed for the infrared light
• CPC Class Codes: G02B 5/283 designed for the ultraviolet
• CPC Class Codes: G02B 5/285 comprising deposited thin solid films G02B5/281 - G02B5/289 take precedence; multilayered film filters for fibre optic multiplexing G02B6/29361
• CPC Class Codes: H01L 27/14621 Colour filter arrangements
• CPC Class Codes: H01L 27/14685 Process for coatings or optical elements

Abstract

Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate modulator to an individual in need thereof. Also provided are methods of enhancing the activity of a serotonin reuptake inhibitor (SRI) comprising co-administering a glutamate modulator and a serotonin reuptake inhibitor. Pharmaceutical composition comprising a serotonin reuptake inhibitor and a glutamate modulator are also provided.

Claims

1. A method of treating generalized anxiety disorder (GAD) in an individual in need thereof, comprising administering to the individual an effective amount of riluzole.

2. The method according to claim 1 wherein said riluzole attenuates presynaptic glutamate release or normalizes, enhances or potentiates the uptake of glutamate by glia.

3. The method according to claim 1 wherein said riluzole increases the expression, activity or function of at least one glutamate transporter in glia.

4. The method according to claim 1 wherein said riluzole is combined with a serotonin reuptake inhibitor or a β

-lactam.

5. The method according to claim 4 wherein riluzole is combined with a serotonin reuptake inhibitor (SRI).

6. The method according to claim 4 wherein riluzole is combined with a β

-lactam.