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IL-17 binding proteins

  • US 8,779,101 B2
  • Filed: 08/05/2013
  • Issued: 07/15/2014
  • Est. Priority Date: 03/05/2009
  • Status: Active Grant
First Claim
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1. A binding protein comprising first and second polypeptide chains, wherein said first polypeptide chain comprises a first VD1-(X1)n-VD2-C-(X2)n, whereinVD1 is a first heavy chain variable domain;

  • VD2 is a second heavy chain variable domain;

    C is a heavy chain constant domain;

    X1 is a linker with the proviso that it is not CH1;

    X2 is an Fc region;

    n is 0 or 1; and

    wherein said second polypeptide chain comprises a second VD1-(X1)n-VD2-C-(X2)n, whereinVD1 is a first light chain variable domain;

    VD2 is a second light chain variable domain;

    C is a light chain constant domain;

    X1 is a linker with the proviso that it is not CH1;

    X2 does not comprise an Fc region;

    n is 0 or 1; and

    wherein the binding protein is capable of binding human IL-17 and TNF-α

    ;

    wherein, in the first polypeptide chain, said VD1 or VD2 heavy chain variable domain comprises an amino acid sequence selected from the group consisting of SEQ ID NOs;

    565, 670, 720, 740, 845, and 875; and

    wherein, in the second polypeptide chain, said VD1 or VD2 light chain variable domain comprises an amino acid sequence selected from the group consisting of SEQ ID NOs;

    570, 675, 725, 745, 850, and 880.

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