Synthesis of UDP-Glucose: N -acylsphingosine glucosyl transferase inhibitors
First Claim
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1. A method of preparing a sphingosine-like compound represented by the following structural formula:
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Abstract
Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
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3 Claims
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1. A method of preparing a sphingosine-like compound represented by the following structural formula:
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2. The method of claim 1 wherein the amine compound is debenzylated by hydrogenation.
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3. The method of claim 2 wherein the amine compound is debenzylated by hydrogenation under a hydrogen atmosphere with a catalytic amount of a hydrogenation catalyst.
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