Swallowable capsule and method for stimulating incretin production within the intestinal tract
First Claim
1. A method for stimulating L-cells in an intestinal track of a patient to secrete a polypeptide, the method comprising:
- ingesting a swallowable device configured to travel through the intestinal tract and electrically stimulate the L-cells at any location in the intestinal tract;
delivering an electrical signal from the device to an intestinal wall proximate the device, wherein the signal includes a waveform configured to electrically stimulate the L-cells in the intestinal tract to secrete the polypeptide without substantially causing a peristaltic contraction.
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Accused Products
Abstract
Embodiments of the invention provide apparatus and methods for stimulating L cells in the intestinal tract to produce incretins for the treatment of conditions including diabetes and obesity. Many embodiments provide a method and apparatus for the treatment of diabetes by electrically stimulating L-cells to secrete incretins to stimulate or otherwise modulate the production of insulin. Particular embodiments provide a swallowable capsule for stimulating L-cells in the intestinal tract as the capsule moves through the tract. The capsule can include two or more electrodes for providing electrical stimulation to L-cells, a power source for powering one or more components of the capsule, a sensor for sensing the location of the capsule in the intestinal tract; a controller and a waveform generator for generating the electrical signals emitted by the electrodes to stimulate the L-cells to secrete incretins such as GLP-1 to stimulate insulin production for glucose regulation of diabetic conditions.
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Citations
30 Claims
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1. A method for stimulating L-cells in an intestinal track of a patient to secrete a polypeptide, the method comprising:
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ingesting a swallowable device configured to travel through the intestinal tract and electrically stimulate the L-cells at any location in the intestinal tract; delivering an electrical signal from the device to an intestinal wall proximate the device, wherein the signal includes a waveform configured to electrically stimulate the L-cells in the intestinal tract to secrete the polypeptide without substantially causing a peristaltic contraction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method for stimulating L-cells in an intestinal track of a patient to secrete an incretin which modulates a release of insulin, the method comprising:
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ingesting a swallowable device configured to travel through the intestinal tract and electrically stimulate the L-cells at any location in the intestinal tract; delivering an electrical signal from the device to an intestinal wall proximate the device, wherein the signal includes a waveform configured to electrically stimulate the L-cells in the intestinal tract to secrete the incretin without causing a peristaltic contraction of a small intestine; and modulating the release of insulin in the patient responsive to the secreted incretin. - View Dependent Claims (25, 26, 27, 28)
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29. A method for stimulating L-cells in an intestinal tract of a patient to secrete an incretin which suppresses an appetite level, the method comprising:
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ingesting a swallowable device configured to travel through the intestinal tract and electrically stimulate the L-cells at any location in the intestinal tract; delivering an electrical signal from the device to an intestinal wall proximate the device, wherein the signal includes a waveform configured to electrically stimulate the L-cells in the intestinal tract to secrete the incretin without causing a peristaltic contraction of a small intestine; and suppressing the appetite level of the patient in response to the secreted incretin. - View Dependent Claims (30)
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Specification