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Optical coherence tomography (OCT) imaging systems having adaptable lens systems and related methods and computer program products

  • US 8,783,866 B2
  • Filed: 04/24/2009
  • Issued: 07/22/2014
  • Est. Priority Date: 04/24/2008
  • Status: Active Grant
First Claim
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1. A scanning Fourier Domain (FD) optical coherence tomography (OCT) imaging system for imaging structures posterior to a lens of an eye of a rodent subject, the system comprising:

  • a source having an associated source arm path;

    a reference arm having an associated reference arm path coupled to the source arm path, the reference arm path having an associated reference arm path length;

    a sample arm having an associated sample arm path coupled to the source arm path, the sample arm comprising;

    an input optical fiber delivering optical radiation from the source;

    at least one optical element following the input optical fiber;

    at least one scanning mirror following the at least one optical element; and

    imaging optics following the at least one scanning mirror, the imaging optics including a plurality of lens elements;

    a reference arm path length adjustment module coupled to the reference arm,wherein the imaging optics of the sample arm images a conjugate of the at least one scanning mirror to a region posterior to the cornea of the rodent subject and anterior to a retina of the rodent subject;

    wherein the imaging optics of the sample arm focus the optical radiation from the input optical fiber to a substantially telecentric conjugate plane, wherein a final objective lens relays a conjugate of the optical radiation from the source to a region posterior to the imaging position of the at least one scanning mirror and substantially within a region of the retina; and

    wherein the reference arm is adjusted to position an OCT image of the retina of the rodent subject within a Fourier domain imaging window.

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