Frozen compositions and array devices thereof

• US 8,784,384 B2
• Filed: 09/15/2009
• Issued: 07/22/2014
• Est. Priority Date: 10/31/2008
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Cook, Daniel B., Hyde, Roderick A., Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): HARWARD, SOREN T
• Application Number:
  US12/586,073
• Publication Number:
  US 20100119557A1
• Time in Patent Office: 1,771 Days
• Field of Search: 604/173
• US Class Current: 604/173
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 2039/54 characterised by the route of administration
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/59 Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 38/38 Albumins
• CPC Class Codes: A61K 38/4833 Thrombin (3.4.21.5)
• CPC Class Codes: A61K 38/4886 Metalloendopeptidases (3.4.24), e.g. collagenase
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 39/12 Viral antigens
• CPC Class Codes: A61K 39/145 Orthomyxoviridae, e.g. influenza virus
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0019 : Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0021 : Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/007 : Pulmonary tract; Aromatherapy
• CPC Class Codes: A61K 9/08 : Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/12 : Aerosols; Foams A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015
• CPC Class Codes: A61K 9/143 : with inorganic compounds
• CPC Class Codes: A61K 9/1611 : Inorganic compounds
• CPC Class Codes: A61K 9/1641 : obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1664 : Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/1617
• CPC Class Codes: A61K 9/1688 : resulting in pure drug agglomerate optionally containing up to 5% of excipient
• CPC Class Codes: A61K 9/19 : lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00
• CPC Class Codes: A61K 9/209 : containing drug in at least two layers or in the core and in at least one outer layer
• CPC Class Codes: A61K 9/2095 : Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing mechanical aspects A61J3/00
• CPC Class Codes: A61K 9/2866 : Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61M 2037/0023 : Drug applicators using microneedles
• CPC Class Codes: A61M 2037/003 : having a lumen
• CPC Class Codes: A61M 2205/02 : characterised by a particular materials
• CPC Class Codes: A61M 37/0015 : by using microneedles
• CPC Class Codes: A61P 17/02 : for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 31/16 : for influenza or rhinoviruses
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: B33Y 80/00 : Products made by additive manufacturing
• CPC Class Codes: C07K 16/22 : against growth factors ; against growth regulators
• CPC Class Codes: C07K 16/283 : against Fc-receptors, e.g. CD16, CD32, CD64 CD23 C07K16/2851
• CPC Class Codes: C07K 16/2842 : against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
• CPC Class Codes: C07K 16/2878 : against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
• CPC Class Codes: C07K 16/30 : from tumour cells
• CPC Class Codes: C12N 2760/16034 : Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
• CPC Class Codes: G16H 20/10 : relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 30/40 : for processing medical images, e.g. editing
• CPC Class Codes: G16H 50/20 : for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/50 : for simulation or modelling of medical disorders
• CPC Class Codes: Y02A 50/30 : Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
• CPC Class Codes: Y10T 83/222 : With receptacle or support for cut product

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. An array device, comprising:

a support structure having a surface; and

a plurality of sterile frozen ice therapeutic composition piercing implements extending substantially outward from the support structure, the implements consisting essentially of sterile ice and including at least one internal channel containing at least one anti-inflammatory agent.

2. The array device of claim 1, wherein the plurality of sterile frozen piercing implements extends substantially perpendicular to the support structure.

3. The array device of claim 1, wherein the support structure includes at least one frozen composition.

4. The array device of claim 1, wherein the support structure is at least partially frozen.

5. The array device of claim 1, wherein the support structure and at least one frozen piercing implement of the plurality of frozen piercing implements include at least one common constituent.

6. The array device of claim 1, wherein the plurality of frozen piercing implements are positioned substantially parallel to each other.

7. The array device of claim 1, wherein the plurality of frozen piercing implements are positioned substantially in a predetermined spatial pattern.

8. The array device of claim 7, wherein the predetermined spatial pattern is at least partially periodic.

9. The array device of claim 1, wherein the plurality of frozen piercing implements include approximately the same length.

10. The array device of claim 1, wherein the length of a frozen piercing implement corresponds to the position or location of the frozen piercing implement in the array device.

11. The array device of claim 1, wherein the length of a frozen piercing implement is actuatable.

12. The array device of claim 1, wherein at least one frozen piercing implement is configured to be deactivated.

13. The array device of claim 12, wherein the at least one frozen piercing implement is configured to be deactivated by at least one component of the array device or the frozen piercing implement.

14. The array device of claim 13, wherein the at least one frozen piercing implement is configured to be deactivated by thermal transfer to the at least one frozen piercing implement.

15. The array device of claim 1, wherein the plurality of frozen piercing implements is positioned as at least a portion of a fluidic or injection device.

16. The array device of claim 1, wherein the plurality of frozen piercing implements is positioned in fluid communication with at least one compartment configured to be mechanically regulated.

17. The array device of claim 1, wherein at least one major dimension includes at least one of the radius, diameter, length, width, height, or perimeter.

18. The array device of claim 1, wherein at least one frozen piercing implement of the plurality further includes at least one vitamin, mineral, cell growth promoter, angiogenic factor, hormone, cytokine, or anesthetic agent.

19. The array device of claim 18, wherein each frozen piercing implement of the plurality includes at least one agent different than the agent of every other frozen piercing implement of the plurality.

20. The array device of claim 18, wherein the device includes at least two different agents.

21. The array device of claim 1, wherein the frozen piercing implement is configured for delivering the at least one agent.

22. The array device of claim 1, wherein at least two frozen piercing implements of the plurality of frozen piercing implements have at least one agent in common.

23. The array device of claim 1, wherein each frozen piercing implement of the plurality of frozen piercing implements is different from every other piercing implement by varying one or more of:

size of implement, shape of implement, or constitution of implement.

24. The array device of claim 1, wherein at least two frozen piercing implements of the plurality of frozen piercing implement differ in one or more of:

size of implement, shape of implement, or constitution of implement.

25. The array device of claim 1, wherein the plurality of frozen piercing implements are arranged in at least one configuration including a regular or irregular shape.

26. The array device of claim 1, wherein the plurality of frozen piercing implements are arranged in at least one configuration including at least one of a rectangle, square, circle, triangle, or polygon.

27. The array device of claim 1, wherein at least one frozen piercing implement of the plurality of frozen piercing implements includes at least one functionalized surface.

28. The array device of claim 27, wherein the at least one functionalized surface includes one or more functionalities including one or more of charge functionality, hydrophobic functionality, hydrophilic functionality, chemically reactive functionality, or wettability.

29. The array device of claim 27, wherein the at least one functionalized surface includes one or more functional groups including at least one of an agent, alcohol, hydroxyl, amine, aldehyde, dye, ketone, carbonyl, thiol, alkoxysilane, phosphate, carboxyl, carboxylic acid, carboxylate, nucleic acid, amino acid, polypeptide, protein, lipid, carbohydrate, metal, —

NH₃⁺, —

COOH, —

COO—

, —

SO₃, CH₂N⁺(CH₃)₃, —

(CH₂)_xCH₃, —

C((CH₂)_xCF₃)₃, —

CH₂N(C₂H₅)₂, —

NH₂, —

(CH₂)_xCOOH, —

(OCH₂CH₂)_xCH₃, —

SiOH, or —

OH.

30. The array device of claim 27, wherein the at least one functionalized surface includes at least part of an outer surface.

31. The array device of claim 27, wherein the at least one functionalized surface includes at least part of an inner surface.

32. The array device of claim 1, wherein at least one frozen piercing implement of the plurality of frozen piercing implements includes at least one inlet port.

33. The array device of claim 1, wherein at least one frozen piercing implement of the plurality of frozen piercing implements includes at least one outlet port.

34. The array device of claim 1, wherein at least one implement of the plurality of frozen piercing implements includes at least one sensor.

35. The array device of claim 1, wherein at least one implement of the plurality of frozen piercing implements is configured for extracting at least one material from at least one substrate.

36. The array device of claim 1, further including at least one attachment component configured to secure the array device to at least one substrate.

37. The array device of claim 36, wherein the at least one attachment component includes at least one adhesive material.

38. The array device of claim 1, wherein the device is configured to substantially form a patch.

39. The array device of claim 1, further including at least one compartment.

40. The array device of claim 39, wherein the at least one compartment includes at least one syringe or at least one valve.

41. The array device of claim 39, wherein the at least one compartment is configured to hold at least one material extracted from at least one substrate.

42. The array device of claim 1, further including at least one of an adhesive agent, reinforcement agent, abrasive, biological remodeling agent, or explosive material.

43. The array device of claim 1, further including at least one compartment in fluid communication with at least one frozen piercing implement of the plurality of frozen piercing implements.

44. The array device of claim 43, wherein the at least one compartment is configured for holding at least one agent.

45. The array device of claim 43, wherein the at least one compartment is configured for holding at least one cryogenic substance.

46. The array device of claim 43, further including a plurality of compartments in fluid communication with at least one frozen piercing implement of the plurality of frozen piercing implements.

47. The array device of claim 46, wherein the plurality of compartments includes at least one first compartment configured to hold at least one different substance from at least one second compartment.

48. The array device of claim 46, wherein the plurality of compartments includes at least one first compartment configured to hold at least one first agent, wherein the at least one first agent is different from at least one other agent located in at least one second compartment.

49. The array device of claim 46, wherein the plurality of compartments includes at least one first compartment configured to hold at least one first agent, and at least one second compartment configured to hold a pharmaceutically acceptable carrier or excipient.

50. The array device of claim 1, wherein the array device is in electronic communication with at least one computing device.

51. The array device of claim 1, further including a heater.

52. An array device, comprising:

a support structure having a surface;

a plurality of sterile frozen ice therapeutic composition piercing implements consisting essentially of sterile ice and extending substantially outward from the support structure, at least one of the plurality of sterile frozen ice therapeutic composition piercing implements including one or more antibiotics;

and an attachment component configured for securing to a biological tissue.