Frozen piercing implements and methods for piercing a substrate

• US 8,784,385 B2
• Filed: 09/15/2009
• Issued: 07/22/2014
• Est. Priority Date: 10/31/2008
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Boyden, Edward S., Cook, Daniel B., Hyde, Roderick A., Leuthardt, Eric C., Myhrvold, Nathan P., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Primary Examiner(s): HARWARD, SOREN T
• Application Number:
  US12/586,076
• Publication Number:
  US 20100111855A1
• Time in Patent Office: 1,771 Days
• Field of Search: 604/173
• US Class Current: 604/173
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 2039/54 characterised by the route of administration
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/59 Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 38/38 Albumins
• CPC Class Codes: A61K 38/4833 Thrombin (3.4.21.5)
• CPC Class Codes: A61K 38/4886 Metalloendopeptidases (3.4.24), e.g. collagenase
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 39/12 Viral antigens
• CPC Class Codes: A61K 39/145 Orthomyxoviridae, e.g. influenza virus
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0019 : Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0021 : Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/007 : Pulmonary tract; Aromatherapy
• CPC Class Codes: A61K 9/08 : Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/12 : Aerosols; Foams A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015
• CPC Class Codes: A61K 9/143 : with inorganic compounds
• CPC Class Codes: A61K 9/1611 : Inorganic compounds
• CPC Class Codes: A61K 9/1641 : obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1664 : Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/1617
• CPC Class Codes: A61K 9/1688 : resulting in pure drug agglomerate optionally containing up to 5% of excipient
• CPC Class Codes: A61K 9/19 : lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00
• CPC Class Codes: A61K 9/209 : containing drug in at least two layers or in the core and in at least one outer layer
• CPC Class Codes: A61K 9/2095 : Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing mechanical aspects A61J3/00
• CPC Class Codes: A61K 9/2866 : Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61M 2037/0023 : Drug applicators using microneedles
• CPC Class Codes: A61M 2037/003 : having a lumen
• CPC Class Codes: A61M 2205/02 : characterised by a particular materials
• CPC Class Codes: A61M 37/0015 : by using microneedles
• CPC Class Codes: A61P 17/02 : for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 31/16 : for influenza or rhinoviruses
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: B33Y 80/00 : Products made by additive manufacturing
• CPC Class Codes: C07K 16/22 : against growth factors ; against growth regulators
• CPC Class Codes: C07K 16/283 : against Fc-receptors, e.g. CD16, CD32, CD64 CD23 C07K16/2851
• CPC Class Codes: C07K 16/2842 : against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
• CPC Class Codes: C07K 16/2878 : against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
• CPC Class Codes: C07K 16/30 : from tumour cells
• CPC Class Codes: C12N 2760/16034 : Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
• CPC Class Codes: G16H 20/10 : relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 30/40 : for processing medical images, e.g. editing
• CPC Class Codes: G16H 50/20 : for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/50 : for simulation or modelling of medical disorders
• CPC Class Codes: Y02A 50/30 : Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
• CPC Class Codes: Y10T 83/222 : With receptacle or support for cut product

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A sterile frozen hydrogen oxide piercing implement, comprising:

sterile frozen hydrogen oxide having a height to width ratio of greater than or equal to 1.5;

1 wherein the frozen hydrogen oxide piercing implement consists essentially of frozen ice and at least one agent, and includes at least one substantially hydrophilic channel; and

wherein the implement is attached to a support structure.

2. The sterile frozen hydrogen oxide piercing implement of claim 1, wherein the implement has at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer, or any value therebetween.

3. The sterile frozen hydrogen oxide piercing implement of claim 1, wherein the at least one agent includes at least one of a therapeutic agent, explosive material, adhesive agent, biological remodeling agent, or abrasive.

4. The sterile frozen hydrogen oxide piercing implement of claim 1, wherein the at least one agent is included as an outer coating of the frozen hydrogen oxide piercing implement.

5. The frozen piercing implement of claim 1, wherein the at least one agent is encapsulated within the frozen piercing implement.

6. The sterile frozen hydrogen oxide piercing implement of claim 1, wherein the at least one agent includes one or more of a prodrug or precursor compound.

7. The sterile frozen hydrogen oxide piercing implement of claim 1, wherein the sterile frozen hydrogen oxide is substantially in one or more phases including at least one of amorphous solid water, low density amorphous ice, high density amorphous ice, very high density amorphous ice, clathrate ice, hyperquenched glassy water, ice Ic, ice Ih, ice II, ice III, ice IV, ice V, ice VI, ice VII, ice VIII, ice IX, ice X, ice XI, ice XII, ice XIII, ice XIV, or ice XV.

8. The frozen piercing implement of claim 1, wherein the frozen piercing implement includes at least one cavity.

9. The sterile frozen hydrogen oxide piercing implement of claim 1, further including at least one detection material.

10. The sterile frozen hydrogen oxide piercing implement of claim 9, wherein the at least one detection material includes at least one of a contrast agent, sensor, or electronic identification device.

11. The sterile frozen hydrogen oxide piercing implement of claim 10, wherein the at least one electronic identification device includes at least one radio frequency identification device.

12. The frozen piercing implement of claim 9, wherein the at least one detection material includes at least one temperature-sensitive substance.

13. The frozen piercing implement of claim 9, wherein the at least one detection material includes at least one of a radioactive, luminescent, colorimetric or odorous substance.

14. The frozen piercing implement of claim 1, wherein the at least one frozen piercing implement includes one or more layers.

15. The sterile frozen hydrogen oxide piercing implement of claim 1, wherein the at least one implement is configured to melt or evaporate prior to, during, or subsequent to contacting the at least one substrate.

16. The sterile frozen hydrogen oxide piercing implement of claim 1, wherein the at least one implement is configured to melt within the at least one substrate.

17. The sterile frozen hydrogen oxide piercing implement of claim 1, wherein the at least one implement is configured to be substantially removed from the at least one substrate.

18. The sterile frozen hydrogen oxide piercing implement of claim 1, further including at least one non-frozen implement holding device.

19. The sterile frozen hydrogen oxide piercing implement of claim 18, wherein the at least one non-frozen implement holding device includes at least one handle, robotic arm, or surgical device.

20. The frozen piercing implement of claim 1, wherein the frozen piercing implement includes at least one port.

21. The frozen piercing implement of claim 20, wherein the at least one port includes at least one side port.

22. The frozen piercing implement of claim 20, wherein the at least one port includes at least one end port.

23. The frozen piercing implement of claim 20, wherein the at least one port includes at least one inlet port or outlet port.

24. The frozen piercing implement of claim 20, wherein the at least one inlet port or outlet port is in fluid communication with at least one channel.

25. The sterile frozen hydrogen oxide piercing implement of claim 1, formulated to be administered to the at least one substrate.

26. The sterile frozen hydrogen oxide piercing implement of claim 1, wherein the at least one substrate includes one or more of a cell, tissue, organ, structure, device, or food product.

27. The sterile frozen hydrogen oxide piercing implement of claim 1, wherein the at least one frozen piercing implement includes at least one sensor.

28. The sterile frozen hydrogen oxide piercing implement of claim 27, wherein the at least one sensor includes at least one sensor configured for detecting at least one of a biochemical, electrical, optical, functional, physical, chemical, biological, or structural characteristic of the at least one material.

29. The sterile frozen hydrogen oxide piercing implement of claim 1, further including a plurality of frozen piercing implements.

30. The sterile frozen hydrogen oxide piercing implement of claim 1, wherein the frozen piercing implement is included in at least one frozen piercing implement device.

31. The sterile frozen hydrogen oxide piercing implement of claim 1, wherein the agent includes one or more of an anti-coagulant, a vaccine, an adjuvant, an anti-agiogenic factor, an anti-inflammatory, an analgesic, or an anti-tumor agent.