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Methods for modulating osteochondral development using bioelectrical stimulation

  • US 8,785,196 B2
  • Filed: 10/14/2010
  • Issued: 07/22/2014
  • Est. Priority Date: 06/03/2005
  • Status: Active Grant
First Claim
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1. A kit for preparing a tissue suitable for transplantation, the kit comprising:

  • cells; and

    an electrical stimulator providing an electrical stimulus waveform that includes a number of consecutive D-type signal pulse bursts that repeat at a fixed interval of 1 second or longer between consecutive pulse bursts;

    wherein each of the number of consecutive D-type signal pulse bursts includes a D-type signal having a frequency of less than 910 Hz, a shorter negative voltage pulse length of between 100 microseconds (μ

    sec) and 1000 μ

    sec in duration, a longer positive voltage pulse length in excess of 1 millisecond in duration, and a pulse burst length of from about 100 milliseconds to about 1 second; and

    wherein the electrical stimulus waveform promotes proliferation, differentiation, or matrix production of the cells into a tissue suitable for transplantation.

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