Compositions with reactive ingredients, and wound dressings, apparatuses, and methods

• US 8,785,713 B2
• Filed: 04/12/2011
• Issued: 07/22/2014
• Est. Priority Date: 04/13/2010
• Status: Active Grant

• Current Assignee: Solventum Intellectual Properties Company (Solventum Corp.)
• Original Assignee: KCI Licensing Incorporated (3M Company)
• Inventors: Hong, Kz, Ingram, Shannon C., Zimnitsky, Dmitry, Long, Justin Alexander, Kazala, Richard M. Jr., Ramirez, Hugo
• Primary Examiner(s): Lewis, Kim M
• Application Number:
  US13/085,041
• Publication Number:
  US 20110257573A1
• Time in Patent Office: 1,197 Days
• Field of Search: 602 41- 59, 427/221, 604304-308
• US Class Current: 602/48
• CPC Class Codes: A61F 13/00072 Packaging of dressings
• CPC Class Codes: A61F 13/05 specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
• CPC Class Codes: A61F 2013/0017 possibility of applying fluid
• CPC Class Codes: A61F 2013/00174 possibility of applying pressure
• CPC Class Codes: A61F 2013/00536 for draining or irrigating wounds
• CPC Class Codes: A61F 2013/0091 with disinfecting or anaesthetics means, e.g. anti-mycrobic
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 26/0095 Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
• CPC Class Codes: A61M 1/85 with gas or fluid supply means, e.g. for supplying rinsing fluids or anticoagulants for negative pressure wound therapy A61M1/92, A61M1/94; combined with tracheal tubes A61M16/0463; dental instruments with combined rinsing and aspirating A61C17/0208
• CPC Class Codes: A61M 1/915 Constructional details of the pressure distribution manifold
• CPC Class Codes: A61M 1/92 with liquid supply means
• CPC Class Codes: A61M 2205/7536 allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes
• CPC Class Codes: A61M 35/00 Devices for applying media, e.g. remedies, on the human body devices for handling toiletry or cosmetic substances A45D; absorbent pads, e.g. swabs, A61F13/15
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 31/02 Local antiseptics

Abstract

Wound dressings and wound inserts comprising substantially dry reactive agents, methods of forming wound inserts comprising dry reactive agents, and wound-treatment methods.

Claims

1. A wound insert, comprising:

an open-celled foam configured to be disposed between a wound of a patient and a drape configured to be coupled to skin adjacent the wound; and

a reactive agent disposed within the foam, and configured to be inert in the absence of an activating fluid and to exhibit antimicrobial properties in the presence of an activating fluid;

wherein the reactive agent is configured to react with water to release hypochlorite ion and/or form hypochlorous acid.

2. The wound insert of claim 1, where the reactive agent comprises a hypochlorite salt defined by M(OCl)n, where n=1 if M is K⁺, Li⁺, or Na⁺, and where n=2 if M is Ca²⁺ or Mg²⁺.

3. The wound insert of claim 1, further comprising

a biocompatible suspension agent that couples the reactive agent to the foam and optionally at least partially encapsulates the reactive agent.

4. The wound insert of claim 3, where the suspension agent comprises polycaprolactone (PCL).

5. The wound insert of claim 3, where the wound insert is configured to release a hypochlorite ion in the presence of a volume of activating liquid such that after release the volume of activating liquid will have a concentration of hypochlorite ion between 0.7 and 20 millimolar (mM).

6. The wound insert of claim 5, where the wound insert is configured to release a hypochlorite ion in the presence of each of three or more sequential volumes of activating liquid such that after release each sequential volume of activating liquid will have a concentration of hypochlorite ion between 0.7 and 20 millimolar (mM).

7. The wound insert of claim 3, where the foam comprises silicone.

8. The wound insert of claim 3, further comprising:

a second open-celled foam that is not coupled to the reactive agent;

where the first open-celled foam is configured to be inert in the present of the reactive agent, and forms a first layer of the wound insert; and

where the second open-celled foam forms a second layer of the wound insert, and is coupled to the first open-celled foam.

9. A wound dressing comprising:

a wound insert comprising;

an open-celled foam configured to be disposed between a wound of a patient and a drape configured to be coupled to skin adjacent the wound;

a reactive agent disposed within the foam, and configured to be inert in the absence of an activating fluid and to exhibit antimicrobial properties in the presence of an activating fluid;

wherein the reactive agent is configured to react with water to release hypochlorite ion and/or form hypochlorous acid; and

a biocompatible suspension agent that couples the reactive agent to the foam and optionally at least partially encapsulates the reactive agent; and

a drape configured to be coupled to skin adjacent a wound of a patient.

10. A wound-treatment apparatus comprising:

a wound insert comprising

an open-celled foam configured to be disposed between a wound of a patient and a drape configured to be coupled to skin adjacent the wound;

a reactive agent disposed within the foam, and configured to be inert in the absence of an activating fluid and to exhibit antimicrobial properties in the presence of an activating fluid;

wherein the reactive agent is configured to react with water to release hypochlorite ion and/or form hypochlorous acid; and

a biocompatible suspension agent that couples the reactive agent to the foam and optionally at least partially encapsulates the reactive agent;

a drape configured to be coupled to skin adjacent a wound of a patient; and

a fluid source configured to be coupled to the wound dressing such that the fluid source is actuatable to deliver a fluid to the wound dressing.

11. The apparatus of claim 10, further comprising:

a vacuum source configured to be coupled to the wound dressing such that the vacuum source is actuatable to apply negative pressure to the wound dressing.

12. A method comprising:

adding hypochlorite salt particles to a solution such that the solution and hypochlorite salt form a slurry, the solution comprising a polymer and a liquid that is a solvent of the polymer but not a solvent of the hypochlorite salt;

substantially removing the liquid from the slurry such that at least a portion of the hypochlorite salt particles are at least partially encapsulated by the polymer.

13. The method of claim 12, where the hypochlorite salt is defined by M(OCl)n, where n=1 if M is K⁺, Li⁺, or Na⁺, and where n=2 if M is Ca²⁺ or Mg²⁺.

14. The method of claim 13, where the hypochlorite salt is defined by Ca(OCl)₂.

15. The method of claim 12, where the polymer is biocompatible and optionally biodegradable.

16. The method of claim 15, where the polymer is not water soluble.

17. The method of claim 16, where the polymer comprises polycaprolactone (PCL).

18. The method of claim 12, where the solvent is non-aqueous.

19. The method of claim 18, where the solvent comprises at least one of Dichloromethane (DCM or methylene chloride), Tetrahydrofuran (THF), or Cyclohexane.

20. The method of claim 12, further comprising:

disposing, prior to substantially removing the liquid, a foam in the slurry such that hypochlorite salt particles and polymer are dispersed within the foam.

21. The method of claim 20, further comprising:

reducing, prior to adding the hypochlorite salt particles into the solution, the size of the hypochlorite salt particles such that a majority of the hypochlorite salt particles have a size at or below a target size.

22. The method of claim 21, where the target size is 180 microns.