Method for spectrophotometric blood oxygenation monitoring

• US 8,788,004 B2
• Filed: 12/12/2011
• Issued: 07/22/2014
• Est. Priority Date: 07/26/2002
• Status: Active Grant

• Current Assignee: Edwards Lifesciences Corporation
• Original Assignee: Cas Medical Systems Incorporated (Edwards Lifesciences Corporation)
• Inventors: Chen, Bo, Benni, Paul B.
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US13/323,479
• Publication Number:
  US 20120108927A1
• Time in Patent Office: 953 Days
• Field of Search: 600/323, 600/331, 600/336, 250/339.09, 250/341.1, 250/341.5, 356/41, 356/319
• US Class Current: 600/323
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue

Abstract

A method and apparatus for non-invasively determining the blood oxygenation within a subject'"'"'s tissue is provided that utilizes a near infrared spectrophotometric (NIRS) sensor capable of transmitting a light signal into the tissue of a subject and sensing the light signal once it has passed through the tissue via transmittance or reflectance.

Claims

1. A method for non-invasively determining an absolute non-pulsatile blood oxygen saturation level within a subject'"'"'s tissue, said method comprising the steps of:

providing a sensor having at least one transducer in communication with a processor, the transducer having at least one light source, a first light detector spaced apart from the light source by a first distance, and a second light detector spaced apart from the light source by a second distance, wherein the first distance is less than the second distance;

transmitting light signals from the light source into the subject'"'"'s tissue, wherein the transmitted light signals include a plurality of wavelengths;

sensing the light signals using the first light detector and the second light detector, and communicating information representative of the sensed light signals to the processor;

determining an attenuation of the transmitted light signals for each of the plurality of wavelengths using the processor to process the information representative of the sensed light signals; and

determining the absolute non-pulsatile blood oxygen saturation level within the subject'"'"'s tissue using the processor, which determining includes determining a difference in attenuation between the plurality of wavelengths.

2. The method of claim 1, further comprising the step of calibrating the sensor to account for energy losses attributable to one or more of light scattering, absorption from biological compounds other than hemoglobin, and apparatus variability.

3. The method of claim 2, wherein the calibrating includes using information representative of a comparison of non-invasively collected oxygen saturation data and invasively collected oxygen saturation data.

4. The method of claim 2, wherein the step of calibrating includes calibrating the sensor to be subject independent.

5. The method of claim 1, further comprising the step of determining one or both of an absolute non-pulsatile oxyhemoglobin concentration value and an absolute non-pulsatile deoxyhemoglobin concentration value.

6. The method of claim 1, further comprising the step of determining an arterial oxygen saturation of the subject using a pulse oximeter.

7. The method of claim 6, further comprising the step of determining a venous oxygen saturation within the subject'"'"'s tissue using the arterial oxygen saturation determined using the pulse oximeter.

8. The method of claim 1, wherein the at least one transducer includes a first transducer and a second transducer, and the step of transmitting light signals includes transmitting light signals from the light source of the first transducer into the subject'"'"'s tissue and transmitting light signals from the light source of the second transducer into the subject'"'"'s tissue;

and

wherein the step of sensing the light signals includes sensing the light signals from the light source of the first transducer using the first and second light detectors of the first transducer, and sensing the light signals from the light source of the second transducer using the first and second light detectors of the second transducer.

9. An apparatus for non-invasively determining an absolute non-pulsatile blood oxygen saturation level within a subject'"'"'s tissue, comprising:

a sensor having at least one transducer, the transducer having at least one light source, a first light detector spaced apart from the light source by a first distance, and a second light detector spaced apart from the light source by a second distance, wherein the first distance is less than the second distance, and a processor in communication with the transducer;

wherein the transducer is operable to transmit light signals from the light source into the subject'"'"'s tissue, wherein the transmitted light signals include a plurality of wavelengths, and is operable to sense the light signals using the first light detector and the second light detector, and communicate information representative of the sensed light signals to the processor;

wherein the processor is adapted to determine an attenuation of the transmitted light signals for each of the plurality of wavelengths using the information representative of the sensed light signals, and is adapted to determine the absolute non-pulsatile blood oxygen saturation level within the subject'"'"'s tissue, which saturation level determination includes determining a difference in attenuation between the plurality of wavelengths.

10. The apparatus of claim 9, wherein the processor is adapted to determine one or both of an absolute non-pulsatile oxyhemoglobin concentration value and an absolute non-pulsatile deoxyhemoglobin concentration value.

11. The apparatus of claim 9, further comprising a pulse oximeter operable to determine an arterial oxygen saturation of the subject.

12. The apparatus of claim 11, wherein the processor is adapted to determine a venous oxygen saturation value within the subject'"'"'s tissue using the arterial oxygen saturation determined using the pulse oximeter.