Neural stimulation system providing auto adjustment of stimulus output as a function of sensed impedance

• US 8,788,056 B2
• Filed: 08/16/2013
• Issued: 07/22/2014
• Est. Priority Date: 02/12/2002
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: King, John D. H., Thacker, James R.
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): GHAND, JENNIFER LEIGH-STEWAR
• Application Number:
  US13/969,388
• Publication Number:
  US 20130331911A1
• Time in Patent Office: 340 Days
• Field of Search: 607/8, 607/43, 607/46, 607/62
• US Class Current: 607/62
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/3615 Intensity

Abstract

A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

Claims

1. A neurostimulation system, comprising:

at least one electrical terminal configured for respectively coupling to at least one electrode implanted within tissue;

stimulation output circuitry configured for outputting stimulation energy to the at least one electrical terminal;

memory configured for storing a look-up table containing impedance changes respectively correlated with predicted stimulation energy adjustments;

monitoring circuitry configured for measuring an impedance change indicative of a variation in a coupling efficiency between the at least one electrode and the tissue; and

a processor configured for analyzing the look-up table to determine the predicted stimulation energy adjustment correlated to the measured impedance change, and automatically adjusting the stimulation energy output by the stimulation output circuitry in accordance with the determined stimulation energy adjustment.

2. The neurostimulation system of claim 1, wherein the processor is configured for automatically adjusting the stimulation energy output by the stimulation output circuitry to the at least one electrical terminal to compensate for the variations in the coupling efficiency by maintaining the stimulation energy delivered to the tissue at a set level.

3. The neurostimulation system of claim 1, wherein the processor is configured for automatically adjusting the stimulation energy output by the stimulation output circuitry to the at least one electrical terminal by varying at least one of a pulse amplitude, pulse width, and pulse frequency of the stimulation energy.

4. The neurostimulation system of claim 1, wherein the processor is configured for analyzing the look-up table by cross-referencing the measured impedance change with the correlated impedance changes to determine the adjustment of the stimulation energy output by the stimulation output circuitry to the at least one electrical terminal.

5. The neurostimulation system of claim 1, wherein the impedance changes are correlated to different postural events.

6. The neurostimulation system of claim 5, wherein the different postural events comprise at least one of sitting to lying, standing to lying, sitting to standing, twisting the torso to one or the other side, standing to sitting, and running.

7. The neurostimulation system of claim 1, wherein the correlated impedance changes are characteristic impedance waveform morphologies, and the measured impedance change comprises a measured characteristic impedance waveform morphology.

8. The neurostimulation system of claim 1, wherein the measured impedance change comprises at least two impedance samples taken over time, and the processor is configured for computing the measured impedance change by comparing the at least two impedance samples to each other.

9. The neurostimulation system of claim 1, further comprising the at least one electrode.

10. The neurostimulation system of claim 1, wherein the monitoring circuitry is configured for measuring the impedance change using the at least one electrode.

11. The neurostimulation system of claim 1, further comprising a sensor separate from the at least one electrode, wherein the monitoring circuitry is configured for measuring the impedance change using the sensor.

12. The neurostimulation system of claim 1, further comprising an implantable pulse generator containing the at least one electrical terminal, the stimulation output circuitry, the memory, the monitoring circuitry, and the processor.

13. A neurostimulation system, comprising:

at least one electrical electrode configured for being implanted within tissue; and

an implantable pulse generator configured for outputting stimulation energy to the at least one electrode, storing a look-up table containing impedance changes respectively correlated with predicted stimulation energy adjustments, measuring an impedance change indicative of a variation in a coupling efficiency between the at least one electrode and the tissue, analyzing the look-up table to determine the predicted stimulation energy adjustment correlated to the measured impedance change, and automatically adjusting the stimulation energy output to the at least one electrode in accordance with the determined stimulation energy adjustment.

14. The neurostimulation system of claim 13, wherein the implantable pulse generator is configured for automatically adjusting the stimulation energy output to the at least one electrode to compensate for the variation in the coupling efficiency by maintaining the stimulation energy delivered to the tissue at a set level.

15. The neurostimulation system of claim 13, wherein the implantable pulse generator is configured for automatically adjusting the stimulation energy output to the at least one electrode by varying at least one of a pulse amplitude, pulse width, and pulse frequency of the stimulation energy.

16. The neurostimulation system of claim 13, wherein the implantable pulse generator is configured for analyzing the look-up table by cross-referencing the measured impedance change with the correlated impedance changes to determine the adjustment of the stimulation energy output by the stimulation output circuitry to the at least one electrode.

17. The neurostimulation system of claim 13, wherein the impedance changes are correlated to different postural events.

18. The neurostimulation system of claim 17, wherein the different postural events comprise at least one of sitting to lying, standing to lying, sitting to standing, twisting the torso to one or the other side, standing to sitting, and running.

19. The neurostimulation system of claim 13, wherein the correlated impedance changes are characteristic impedance waveform morphologies, and the measured impedance change comprises a measured characteristic impedance waveform morphology.

20. The neurostimulation system of claim 13, wherein the measured impedance change comprises at least two impedance samples taken over time, and the implantable pulse generator is configured for computing the measured impedance change by comparing the at least two impedance samples to each other.

21. The neurostimulation system of claim 13, wherein the implantable pulse generator is configured for measuring the impedance change using the at least one electrode.

22. The neurostimulation system of claim 13, further comprising a sensor separate from the at least one electrode, wherein the implantable pulse generator is configured for measuring the impedance change using the sensor.