Methods and system for performing remote ischemic preconditioning
First Claim
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1. A method of performing remote ischemic preconditioning to render tissue resistant to injury during subsequent ischemic episodes, the method comprising:
- positioning a cuff about a limb of a subject at a location remote from the tissue being rendered resistant;
initiating a treatment protocol that is controlled by a controller and that includes a plurality of treatment cycles that include at least a first treatment cycle and a second treatment cycle;
the first treatment cycle comprising;
compressing the limb of the subject with pressure applied by the cuff to occlude blood flow through the limb for a first ischemic duration that lasts for at least a minute; and
releasing pressure applied to the limb by the cuff to allow blood flow through the limb for a first reperfusion duration that lasts at least one minute;
the second treatment cycle comprising;
compressing the limb of the subject with pressure applied by the cuff to occlude blood flow through the limb for a second ischemic duration that lasts for at least a minute; and
releasing pressure applied to the limb by the cuff to allow blood flow through the limb for a second reperfusion duration that lasts at least one minute; and
removing the cuff from the limb of the subject.
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Abstract
A system for remote ischemic preconditioning that includes a cuff, and actuator, and a controller that operates the actuator according to a treatment protocol. The treatment protocol includes a plurality of treatment cycles that each comprise cuff actuation, an ischemic duration, cuff release, and a reperfusion duration.
87 Citations
22 Claims
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1. A method of performing remote ischemic preconditioning to render tissue resistant to injury during subsequent ischemic episodes, the method comprising:
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positioning a cuff about a limb of a subject at a location remote from the tissue being rendered resistant; initiating a treatment protocol that is controlled by a controller and that includes a plurality of treatment cycles that include at least a first treatment cycle and a second treatment cycle; the first treatment cycle comprising; compressing the limb of the subject with pressure applied by the cuff to occlude blood flow through the limb for a first ischemic duration that lasts for at least a minute; and releasing pressure applied to the limb by the cuff to allow blood flow through the limb for a first reperfusion duration that lasts at least one minute; the second treatment cycle comprising; compressing the limb of the subject with pressure applied by the cuff to occlude blood flow through the limb for a second ischemic duration that lasts for at least a minute; and releasing pressure applied to the limb by the cuff to allow blood flow through the limb for a second reperfusion duration that lasts at least one minute; and removing the cuff from the limb of the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of performing remote ischemic preconditioning to render tissue resistant to injury during subsequent ischemic episodes, the method comprising:
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positioning a cuff about a limb of a subject at a location remote from the tissue being rendered resistant; initiating a treatment protocol that is controlled by a controller and that includes a plurality of sequentially actuated treatment cycles, including a first treatment cycle, a second treatment cycle, and a third treatment cycle; the first treatment cycle comprising; compressing the limb of the subject with pressure applied by the cuff to occlude blood flow through the limb for a first ischemic duration that lasts for at least a minute; and releasing pressure applied to the limb by the cuff in to allow blood flow through the limb for a first reperfusion duration that lasts at least one minute; the second treatment cycle comprising; compressing the limb of the subject with pressure applied by the cuff to occlude blood flow through the limb for a second ischemic duration that lasts for at least a minute; and releasing pressure applied to the limb by the cuff to allow blood flow through the limb for a second reperfusion duration that lasts at least one minute; the third treatment cycle comprising; compressing the limb of the subject with pressure applied by the cuff to occlude blood flow through the limb for a third ischemic duration that lasts for at least a minute; and releasing pressure applied to the limb by the cuff to allow blood flow through the limb; and removing the cuff from the limb of the subject. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A system for remote ischemic preconditioning, the system comprising:
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a cuff configured to contract about a limb of a subject; an actuator connected to the cuff and that, when actuated, causes the cuff to contract about the limb of the subject to reduce blood flow therethrough; and a controller that controls the actuator to operate according to a treatment protocol that includes a plurality of sequentially actuated treatment cycles, each treatment cycle comprising; cuff actuation, during which the actuator contracts the cuff about the limb of the subject to a pressure to occlude blood flow through the limb; an ischemic duration, during which the cuff is contracted about the limb to occlude blood flow though the limb, the ischemic duration lasting for at least about a minute; cuff release, during which the actuator releases the cuff to allow blood flow through the limb; and a reperfusion duration, during which the cuff is in an at least partially relaxed state to allow blood flow through the limb, the reperfusion duration lasting for at least one minute. - View Dependent Claims (20, 21, 22)
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Specification