Dynamically variable filter

• US 8,790,267 B2
• Filed: 08/11/2008
• Issued: 07/29/2014
• Est. Priority Date: 08/13/2007
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Cheetah Medical, Inc. (Baxter International Inc.)
• Inventors: Keren, Hanan, Avidor, Yoav, Squara, Pierre, Burkhoff, Daniel, Levy, Baruch
• Primary Examiner(s): Heller, Tammie K
• Application Number:
  US12/673,037
• Publication Number:
  US 20110218419A1
• Time in Patent Office: 2,178 Days
• Field of Search: 600/508, 600/526
• US Class Current: 600/528
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61B 5/725 using specific filters therefor, e.g. Kalman or adaptive filters A61B5/316 take precedence
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

A method of processing a signal pertaining to at least one electrical property of an organ of a subject is disclosed. The method comprises determining a physiological condition of the subject, selecting a frequency band, filtering the signal according to the frequency band, and dynamically adapting the frequency band in response to a change in the physiological condition.

Claims

1. A method of analyzing an input radiofrequency signal sensed from an organ of a subject, comprising:

processing said input radiofrequency signal to provide a processed input signal, wherein said processing comprises determining a phase shift of said input signal relative to an output radiofrequency signal transmitted to the organ;

filtering said processed signal using a dynamically variable band pass filter, thereby providing a filtered signal; and

using said filtered signal and said phase shift for calculating at least one of;

a stroke volume, a cardiac output, a brain intra luminal blood volume and blood flow;

wherein the method further comprising executing an iterative process to dynamically update an upper frequency bound of said filter in response to a change in a physiological condition of the subject.

2. The method of claim 1, wherein said possessing comprises filtering said input radiofrequency signal using an analog filter.

3. The method of claim 1, wherein said blood flow comprises at least one of:

an external carotid blood flow rate, an internal carotid blood flow rate, an ulnar blood flow rate, a radial blood flow rate, a brachial blood flow rate, a common iliac blood flow rate, an external iliac blood flow rate, a posterior tibial blood flow rate, an anterior tibial blood flow rate, a peroneal blood flow rate, a lateral plantar blood flow rate, a medial plantar blood flow rate and a deep plantar blood flow rate.

4. The method of claim 1, further comprising transmitting said output radiofrequency signal to the organ and sensing said input radiofrequency signal from the organ.

5. The method of claim 1, further comprising reducing or eliminating amplitude modulation of said input radiofrequency signal, so as to provide a signal of substantially constant envelope.

6. The method of claim 5, wherein said reducing or eliminating said amplitude modulation comprises maintaining a phase modulation of said input radiofrequency signal.

7. The method of claim 1, wherein said physiological condition is a heart rate of the subject.

8. The method of claim 7, wherein at least one of a lower frequency bound and an upper frequency bound characterizing said filter is a linear function of said heart rate.

9. The method of claim 8, wherein said lower frequency bound is about 0.9*(HR/60) Hz at all times, wherein said HR is said heart rate in units of beats per minute.

10. The method of claim 7, wherein said heart rate is determined from an ECG signal received from said subject.

11. The method of claim 7, wherein an initial value of said upper frequency bound in said iterative process is a linear function of said heart rate.

12. The method of claim 11, wherein an initial value of said upper frequency bound in said iterative process is about 6+1.5*[(HR/60)−

1] Hz, wherein said HR is said heart rate in units of beats per minute.

13. The method of claim 1, wherein said iterative process is based on a comparison between a value of a physiological parameter as extracted from said filtered input signal and a value of said physiological parameter as extracted from a reference signal.

14. The method of claim 13, wherein said reference signal comprises an ECG signal.

15. The method of claim 13, wherein each iteration of said iterative process comprises:

if said comparison meets a predetermined criterion, then updating said upper frequency bound by calculating an average between a low threshold and a high threshold;

said thresholds being predetermined or set in a previous iteration of said iterative process.

16. The method of claim 13, wherein said physiological parameter is a ventricular ejection time (VET).

17. The method of claim 16, wherein said VET is averaged over a plurality of heart beats.

18. The method of claim 16, wherein said VET is extracted from an average heart beat morphology of the subject.

19. The method of claim 1, wherein said input radiofrequency signal is indicative of impedance of the organ.

20. The method of claim 1, wherein said input radiofrequency signal is indicative of hemodynamic reactance of the organ.

21. Apparatus for analyzing an input radiofrequency signal sensed from an organ of a subject, comprising:

an input unit for receiving the input radiofrequency signal;

a signal processing circuit configured for processing said input radiofrequency signal to provide a processed input signal, said processing unit comprising a phase shift determinator configured for determining a phase shift of said input signal relative to an output radiofrequency signal transmitted to the organ;

a filtering unit configured for filtering said processed signal using a dynamically variable band pass filter, to thereby provide a filtered signal; and

a data processor having a circuit configured for applying an iterative process to dynamically update an upper frequency bound of said filter in response to a change in a physiological condition of the subject, and for calculating at least one quantity based on said phase shift, wherein said at least one quantity is selected from the group consisting of a stroke volume, a cardiac output, a brain intra luminal blood volume and blood flow.

22. The apparatus of claim 21, wherein said physiological condition is a heart rate of the subject.

23. The apparatus of claim 22, wherein an initial value of said upper frequency bound in said iterative process is a linear function of said heart rate.

24. The apparatus of claim 23, wherein an initial value of said upper frequency bound in said iterative process is about 6+1.5*[(HR/60)−

1] Hz, wherein said HR is said heart rate in units of beats per minute.

25. The apparatus of claim 21, wherein said signal processing unit comprises an envelope elimination unit designed and configured to reduce or eliminate amplitude modulation of said filtered signal, so as to provide a signal of substantially constant envelope.

26. The apparatus of claim 25, wherein said envelope elimination unit is designed and configured to maintain a phase modulation of said signal.

27. A system for monitoring at least one electrical property of an organ of a subject, comprising:

a radiofrequency generator for generating an output radiofrequency signal;

a plurality of electrodes, designed to be connectable to the skin of the subject, said electrodes being for transmitting said output radiofrequency signal to the organ and for sensing an input radiofrequency signal from the organ; and

the apparatus according to claim 21.