Measuring multi-analyte samples using an in-line flow cell
First Claim
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1. A system for processing a sample, the system comprising:
- a low pressure flow cell having an entrance and an exit;
a low pressure pump system fluidly coupled to the entrance of the flow cell, the pump system configured to move a sample into the flow cell;
a detector functionally attached to the flow cell;
a first transition valve fluidly coupled to the exit of the flow cell; and
a controller configured to determine when a fixed mass of hemoglobin of a portion of the sample has flowed through the flow cell based on a signal from the detector, the controller being configured to switch the first transition valve based on a predetermined quantity of the fixed mass of hemoglobin in order to route the portion of the sample containing the fixed mass of hemoglobin, and the controller being further configured to apply a low pressure through the flow cell.
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Abstract
Methods and systems for analyzing ratios of analytes within a flowing sample are provided. The flowing sample can be processed in real-time to determine a time interval over which a predetermined amount of a group of analytes passes by a fixed point in a flow cell. The predetermined amount can be routed to a sample container for future processing. The sample can comprise diluted blood and the analytes can comprise a component of hemoglobin, such as A1c, and the total amount of hemoglobin, of which the predetermined amount is metered.
9 Citations
17 Claims
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1. A system for processing a sample, the system comprising:
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a low pressure flow cell having an entrance and an exit; a low pressure pump system fluidly coupled to the entrance of the flow cell, the pump system configured to move a sample into the flow cell; a detector functionally attached to the flow cell; a first transition valve fluidly coupled to the exit of the flow cell; and a controller configured to determine when a fixed mass of hemoglobin of a portion of the sample has flowed through the flow cell based on a signal from the detector, the controller being configured to switch the first transition valve based on a predetermined quantity of the fixed mass of hemoglobin in order to route the portion of the sample containing the fixed mass of hemoglobin, and the controller being further configured to apply a low pressure through the flow cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification