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Treatment of ‘C terminus of HSP70-interacting protein’ (CHIP)related diseases by inhibition of natural antisense transcript to CHIP

  • US 8,791,087 B2
  • Filed: 08/20/2010
  • Issued: 07/29/2014
  • Est. Priority Date: 08/21/2009
  • Status: Active Grant
First Claim
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1. A method of upregulating a function of and/or the expression of a ‘

  • C terminus of HSP70-Interacting Protein’

    (CHIP) polynucleotide in patient cells or tissues in vivo or in vitro comprising;

    contacting said cells or tissues with at least one single stranded antisense oligonucleotide 15 to 30 nucleotides in length or a double stranded oligonucleotide 19-30 nucleotides in length wherein at least one strand of said at least one oligonucleotide leas at least 80% sequence identity to a reverse complement of a polynucleotide comprising 15 to 30 or 19-30 consecutive nucleotides within nucleotides 1 to 2074 of SEQ ID NO;

    2 and 1 to 1237 of SEQ ID NO;

    3;

    thereby upregulating a function of and/or the expression of the ‘

    C terminus of HSP70-Interading Protein’

    (CHIP) polynucleotide in patient cells or tissues in vivo or in vitro.

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