Analyte monitoring: stabilizer for subcutaneous glucose sensor with incorporated antiglycolytic agent
First Claim
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1. A method for monitoring a level of an analyte in a subject, the method comprising:
- positioning an electrochemical sensor into skin of a subject, wherein the sensor comprises;
a working electrode comprising a sensing layer thereon;
a counter electrode; and
an antiglycolytic agent or precursor thereof chemically bonded to a chelating agent, wherein the antiglycolytic agent or precursor thereof and the chelating agent are disposed proximate to the working electrode, anddetermining a level of an analyte over a period of time from signals generated by the sensor;
wherein the determining over a period of time provides for monitoring the level of the analyte in the subject.
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Abstract
An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.
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Citations
23 Claims
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1. A method for monitoring a level of an analyte in a subject, the method comprising:
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positioning an electrochemical sensor into skin of a subject, wherein the sensor comprises; a working electrode comprising a sensing layer thereon; a counter electrode; and an antiglycolytic agent or precursor thereof chemically bonded to a chelating agent, wherein the antiglycolytic agent or precursor thereof and the chelating agent are disposed proximate to the working electrode, and determining a level of an analyte over a period of time from signals generated by the sensor; wherein the determining over a period of time provides for monitoring the level of the analyte in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for monitoring a level of an analyte in a subject, the method comprising:
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contacting an antiglycolytic agent or precursor thereof chemically bonded to a chelating agent on an analyte determination site on skin of a subject; positioning an electrochemical sensor into the skin of a subject at the analyte determination site, wherein the sensor comprises; a working electrode comprising a sensing layer thereon; a counter electrode; and determining a level over a period of time of an analyte from signals generated by the sensor; wherein the determining over a period of time provides for monitoring the level of the analyte in the subject. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification