Compositions and methods for therapeutic delivery with frozen particles
First Claim
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1. A method, comprising:
- administering at least one solid frozen particle therapeutic composition including at least one tracer agent at high speed to at least one subject, and with use of at least one computing device, comparing information regarding at least one aspect of administering the at least one solid frozen particle therapeutic composition to the at least one subject based on the real-time feedback signal from the at least one tracer agent, and information regarding at least one clinical outcome following receipt by the at least one subject of at least one solid frozen particle therapeutic composition; and
providing output information regarding at least one aspect of the administering the at least one solid frozen particle therapeutic composition to the at least one subject based on the real-time feedback signal from the at least one tracer agent;
wherein the output information is in the form of at least one of a code indicative of at least one vaccination delivered, a code indicative of at least one therapeutic agent delivered, a code indicative of at least one diagnostic agent delivered, a code indicative of at least one interaction of a delivered agent and at least one biological or chemical agent in the subject, a code indicative of at least one detection material delivered, a code indicative of the depth of penetration of a delivered agent, or a code indicative of the condition of at least one location of an administered frozen particle composition.
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Abstract
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
312 Citations
53 Claims
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1. A method, comprising:
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administering at least one solid frozen particle therapeutic composition including at least one tracer agent at high speed to at least one subject, and with use of at least one computing device, comparing information regarding at least one aspect of administering the at least one solid frozen particle therapeutic composition to the at least one subject based on the real-time feedback signal from the at least one tracer agent, and information regarding at least one clinical outcome following receipt by the at least one subject of at least one solid frozen particle therapeutic composition; and providing output information regarding at least one aspect of the administering the at least one solid frozen particle therapeutic composition to the at least one subject based on the real-time feedback signal from the at least one tracer agent; wherein the output information is in the form of at least one of a code indicative of at least one vaccination delivered, a code indicative of at least one therapeutic agent delivered, a code indicative of at least one diagnostic agent delivered, a code indicative of at least one interaction of a delivered agent and at least one biological or chemical agent in the subject, a code indicative of at least one detection material delivered, a code indicative of the depth of penetration of a delivered agent, or a code indicative of the condition of at least one location of an administered frozen particle composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method of predicting a clinical outcome of administering at least one solid frozen particle therapeutic composition to at least one biological tissue of at least one first subject, comprising:
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administering at high speed at least one solid frozen particle therapeutic composition including at least one tracer agent, to at least one biological tissue of at least one first subject and to at least one biological tissue of at least one second subject, and with the use of at least one computing device, determining a similarity or a dissimilarity in information regarding at least one aspect of administering the at least one solid frozen particle therapeutic composition to the at least one biological tissue of the at least one first subject to information regarding at least one aspect of administering at least one solid frozen particle therapeutic composition to the at least one biological tissue of the at least one second subject based on real-time feedback of the detected at least one tracer agent, wherein the at least one second subject attained a clinical outcome following receipt of the at least one solid frozen particle therapeutic composition; and providing output information regarding at least one aspect of the administering the at least one solid frozen particle therapeutic composition to the at least one biological tissue of at least one subject based on the real-time feedback signal from the at least one tracer agent. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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Specification