Sub-motor-threshold stimulation of deep brain targets using transcranial magnetic stimulation

• US 8,795,148 B2
• Filed: 10/26/2010
• Issued: 08/05/2014
• Est. Priority Date: 10/26/2009
• Status: Active Grant

• Current Assignee: Brainsway, Ltd.
• Original Assignee: Cervel Neurotech, Inc.
• Inventors: Schneider, M. Bret, Mishelevich, David J.
• Primary Examiner(s): LACYK, JOHN P
• Application Number:
  US12/912,650
• Publication Number:
  US 20110098779A1
• Time in Patent Office: 1,379 Days
• Field of Search: 600 9- 15, 607 2- 3
• US Class Current: 600/14
• CPC Class Codes: A61N 2/004 specially adapted for a specific therapy
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

Systems and methods for modulating deep brain target regions using an array of TMS electromagnets, wherein each TMS electromagnet stimulates the target at a level that is below motor threshold (MT). Neurological disorders (or disorders having neurological effects) may be treated by sub-MT stimulation of deep-brain targets from an array of TMS electromagnets.

Claims

1. A method of modulating a deep brain target using low power stimulation, the method comprising:

aiming a plurality of TMS electromagnets at a deep brain target; and

applying power to each of the TMS electromagnets at a level that is below the motor threshold (MT) at the target, thereby modulating the activity of the deep brain target.

2. The method of claim 1, further comprising identifying the deep brain target.

3. The method of claim 1, wherein the step of aiming comprising orienting the apex or face of each TMS electromagnet so that the central axis of the applied magnetic field intersects the target.

4. The method of claim 1, wherein the deep brain target is the cingulate.

5. The method of claim 1, wherein the deep brain target is the insula.

6. The method of claim 1, wherein the power applied to one or more TMS electromagnets is below the motor threshold for neuronal regions between the target and the plurality of TMS electromagnets.

7. A method of treating a disorder by deep brain transcranial magnet stimulation, the method comprising:

identifying a target deep brain region associated with the disorder;

aiming a TMS electromagnet at the target deep brain region; and

applying power to the TMS electromagnet at a level that is below the motor threshold (MT) at the target deep brain region to modulate the activity of the target deep brain region.

8. The method of claim 7, further comprising aiming a second TMS electromagnet at a neuronal target.

9. The method of claim 8, wherein the neuronal target modulates the activity of the target deep brain region.

10. The method of claim 8, further comprising up-regulating both the target deep brain region and the neuronal target.

11. The method of claim 8, further comprising down-regulating the target deep brain region and the neuronal target.

12. The method of claim 8, further comprising up-regulating the target deep brain region and down-regulating the neuronal target.

13. The method of claim 7, wherein the target deep brain region is the cingulate.

14. The method of claim 7, wherein the target deep brain region is the insula.

15. The method of claim 7, wherein the disorder is selected from the group consisting of:

pain, depression, addiction, Alzheimer'"'"'s disease, attention deficit disorder, autism, anorgasmia, cerebral palsy, bipolar depression, unipolar depression, epilepsy, generalized anxiety disorder, acute head trauma, hedonism, obesity, OCD, acute pain, chronic pain, Parkinson'"'"'s disease, persistent vegetative state, phobia, post-traumatic stress disorder, rehabilitation/regenesis for post-stroke, post- head trauma, social anxiety disorder, Tourette'"'"'s Syndrome, hemorrhagic stroke, and ischemic stroke.

16. A method of treating a disorder by deep brain transcranial magnet stimulation, the method comprising:

identifying a target deep brain region;

aiming a plurality of TMS electromagnets at the target deep brain region; and

applying power to the plurality of TMS electromagnets at a level that is below the motor threshold (MT) at the target deep brain region to modulate the activity of the target deep brain region.