System and method for providing closed loop infusion formulation delivery
First Claim
1. A method for delivering an insulin formulation, the method comprising:
- taking a plurality of samples of a blood glucose level over a period of time;
calculating a difference between the blood glucose level of each of the plurality of samples and a predefined blood glucose level threshold;
calculating a rate of change over time in the blood glucose level of each of the plurality of samples;
calculating a sum comprising a first proportion of said calculated difference and a second proportion of said calculated rate of change, the second proportion including a trend term based on a timeframe; and
delivering an amount of insulin formulation based on an amount of said sum,wherein the trend term is disabled if the blood glucose level of each of the plurality of samples is less than the predefined blood glucose level threshold.
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Abstract
A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm'"'"'s programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.
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Citations
20 Claims
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1. A method for delivering an insulin formulation, the method comprising:
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taking a plurality of samples of a blood glucose level over a period of time; calculating a difference between the blood glucose level of each of the plurality of samples and a predefined blood glucose level threshold; calculating a rate of change over time in the blood glucose level of each of the plurality of samples; calculating a sum comprising a first proportion of said calculated difference and a second proportion of said calculated rate of change, the second proportion including a trend term based on a timeframe; and delivering an amount of insulin formulation based on an amount of said sum, wherein the trend term is disabled if the blood glucose level of each of the plurality of samples is less than the predefined blood glucose level threshold. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system for delivering an insulin formulation, the system comprising:
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a data acquisition unit for taking a plurality of samples of a blood glucose level over a period of time; a calculator for calculating a difference between the blood glucose level of each of the plurality of samples and a predefined blood glucose level threshold; wherein said calculator is further configured to calculate a rate of change over time in the blood glucose level of each of the plurality of samples acquired by the data acquisition unit; wherein said calculator is further configured to calculate a sum comprising a first proportion of said calculated difference and a second proportion of said calculated rate of change, the second proportion including a trend term based on a timeframe; and a controller for basing an amount of insulin formulation to be delivered on an amount of said sum, wherein the trend term is disabled if the blood glucose level of each of the plurality of samples is less than the predefined blood glucose threshold. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification