Resorbable polymeric device for localized drug delivery

• US 8,795,242 B2
• Filed: 02/12/2005
• Issued: 08/05/2014
• Est. Priority Date: 05/13/1994
• Status: Expired due to Fees

• Current Assignee: Kensey Nash Corporation (DSM-Firmenich AG)
• Original Assignee: Kensey Nash Corporation (DSM-Firmenich AG)
• Inventors: Hoganson, David M., Bradica, Gino, Goldman, Scott M., Brekke, John H.
• Primary Examiner(s): Vu, Quynh-Nhu H
• Assistant Examiner(s): LEE, BRANDY SCOTT
• Application Number:
  US11/056,879
• Publication Number:
  US 20050177118A1
• Time in Patent Office: 3,461 Days
• Field of Search: 424/424, 604/288.01, 60428802-28804, 604/11
• US Class Current: 604/288.01
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 35/16 Blood plasma; Blood serum umbilical cord blood A61K35/51
• CPC Class Codes: A61K 35/28 Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• CPC Class Codes: A61K 38/15 Depsipeptides; Derivatives thereof
• CPC Class Codes: A61L 2430/20 for reconstruction of the heart, e.g. heart valves
• CPC Class Codes: A61L 27/3641 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61L 27/3839 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body

Abstract

An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. In one embodiment, the device is arranged for the local delivery of therapeutic agent. A preferred embodiment is a porous resorbable implant, wherein the therapy delivery may be localized in nature, rather than systemic, such that higher doses at the target site may be allowed than would be tolerable by the body systemically.

Claims

1. A device for implant in a living being, said device comprising:

a porous, resorbable construct having a body terminating in an agent delivery surface arranged to deliver at least one therapeutic agent to target tissue in contact with said agent delivery surface, the body comprising an open porous macrostructure that, at least at a time of implantation, is customizable in size by at least one of compressing, severing, stretching, or connecting to another of said device;

a filament having at least one end arranged to extend out of the living being; and

a delivery tube comprising a proximal end, a distal end, and at least two lumens extending therebetween, wherein one lumen comprises a delivery lumen and another lumen comprises a lumen for said filament, wherein said filament extends within said deliver tube and releasably attaches said distal end of said delivery tube to said porous construct.

2. The device of claim 1, further comprising a connector port, and wherein said delivery tube attaches to said porous construct at said connector port.

3. The device of claim 2, wherein said connector port comprises a groove, and at least a portion of said filament lies in said groove.

4. The device of claim 1, further comprising a connector, and wherein said proximal end of said delivery tube is attached to said, connector.

5. The device of claim 4, wherein said connector lies outside of the living being.